Bioactive compounds are most frequently identified via high-throughput screening campaigns. This article discusses the strengths and weaknesses of the most popular screening approaches and the utility of compounds derived from them.
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Acknowledgements
I thank G. Micalizo, P. MacDonald and P. LoGrasso (Scripps Florida) for comments on the manuscript and the US National Institutes of Health (DP10D00066301) for support.
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Kodadek, T. Rethinking screening. Nat Chem Biol 6, 162–165 (2010). https://doi.org/10.1038/nchembio.303
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DOI: https://doi.org/10.1038/nchembio.303
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