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A potent and selective inhibitor of the kinase LRRK2 identified using an in vitro ATP-site competition binding assay also inhibits the G2019S mutant, implicated in Parkinson's disease, as well as the regulatory feedback loop where LRRK2 is phosphorylated and binds 14-3-3 protein.
Assisted by 3,800 chemical bioactivities, a bioinformatic analysis explores the inter-relatedness of over 170 kinases and generates a kinase interaction map based on sequence and ligand-binding activity that challenges the robustness of drug interaction networks.
The mechanisms and molecules involved in controlling biomineral formation remain unclear, though several proteins have been implicated in the process. Examination of crayfish now surprisingly points to upregulated glycolytic metabolites as playing a critical role in stabilizing amorphous calcium carbonate.
The structural revision of sublancin, previously thought to be a lantibiotic, instead reveals an unusual S-linked carbohydrate that is installed by a glycosyl transferase specific for thiols but promiscuous in its sugar substrates.
