Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Kang et al. find that vitamin B12 from gut bacteria modulates host neural function and behaviour in Caenorhabditis elegans: vitamin B12 rewires the methionine/S-adenosylmethionine cycle and choline metabolism, impacting free choline levels for neuronal acetylcholine synthesis.
Lee et al. use three-dimensional cell reconstruction of focused ion beam scanning electron microscopy data and multi-omics to show that ether-lipid metabolism regulates inter-organelle biogenesis and dynamics.
Giafaglione et al. define metabolic regulation of prostate epithelial lineage identity and show that modulation of lactate metabolism alters response to antiandrogen therapy.
Gerber-Ferder et al. show that non-metastatic breast tumours remotely reprogram the bone marrow stroma and instruct the myeloid differentiation of long-term haematopoietic stem cells.
Gao et al. report that leptin receptor+ stromal cells sustain nerves in the bone marrow by producing nerve growth factor. After myeloablation, nerves promote marrow regeneration by increasing the production of multiple growth factors by leptin receptor+ cells.
McHugh et al. identify COPI trafficking as a vulnerability of senescent cells. N-myristoyltransferase inhibitors phenocopy COPI inhibition and are potent senolytics.
Noack and Vangelisti et al. present 3DRAM-seq, which simultaneously profiles genome organization, chromatin accessibility and DNA methylation at high resolution and allows mapping cell-type-specific epigenetic regulation in human neurogenesis.
Kumari et al. show that host-derived extracellular vesicles capture systemic LPS and transfer it to the cytosol of immune cells via CD14-dependent endocytosis, triggering caspase-11-mediated gasdermin D activation and pyroptosis.
Evans, Blake, Longworth and colleagues identify and characterize a tumour-suppressive role for microglia that mediate a pro-inflammatory response to restrict brain metastasis in breast cancer.
Munk et al. show that exogenous NAD+, but not its precursors, induces metabolic changes in mitochondria affecting nucleotide metabolism with impacts on genomic DNA synthesis and genome integrity.
Liu et al. describe mitopherogenesis: the secretion of mitochondria in mitophers during sperm development in Caenorhabditiselegans, which is important to control the mitochondrial pool and ensure fertility.
Llorente, Blasco, Espuny and colleagues show that MAF regulates the genomic distribution of ERα and modulates the expression of metastasis genes via KDM1A, thereby driving metastatic spread in breast cancer.
Chen et al. report that the YTHDF family of m6A-RNA-binding proteins can be differentially regulated by the post-translational modification O-GlcNAcylation, leading to differential regulation of the YTHDF proteins on translation and phase separation.
Sha et al. show that Borealin is a non-canonical methylation substrate for MLL1 that regulates phase separation of the inner centromeric chromosome passenger complex, and dictates genome integrity and tumour development in hepatocellular carcinoma.
Takakuwa, Yamazaki et al. show that the long noncoding RNA NEAT1 domains specify a set of proteins that localize to the outer shell and distinguish nuclear speckles from paraspeckles to preserve their structural identity.
Through a CRISPR-activation screen, Ravid Lustig et al. show that GATA transcription factors activate long-range Xist enhancers to upregulate Xist expression and initiate X chromosome inactivation in early mouse embryos.
Monteiro et al. show an alternating distribution of caveolae and invadosomes along collagen fibrils, whereby caveolae enhance integrin-mediated collagen uptake in an invadosome-activity-dependent manner to coordinate adhesion and extracellular matrix remodelling.
Wang et al. report that the secretory coat protein complex COPII undergoes liquid–liquid phase separation that is tuned by manganese in the cytosol, to impact lipoprotein secretion.
Subramanian et al. show that the secreted Legionella protein SidI is a tRNA mimic and glycosyltransferase. SidI inhibits host cell translation by mannosylating ribosomes to induce ribosome collisions and trigger the ribotoxic stress response.