Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Austen et al. generated talin biosensors to study integrin-based force transduction. They report that extracellular rigidity sensing requires talin’s mechanical engagement and find talin isoform-dependent effects in integrin-mediated mechanosensing.
Pucadyil and colleagues develop an in vitro technique to analyse the conformational dynamics of dynamin during membrane fission events in a real-time, high-throughput manner, using fluorescence microscopy.
Magness and colleagues present a microwell-based culture system to analyse interactions between intestinal stem cells (ISCs) and Paneth cells, and show that their direct contact enhances formation of ISC-derived organoids.