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Schroeder and colleagues review the development and application of single-cell technologies — from gene and protein expression to clonal labelling, lineage tracing and time-lapse imaging — in stem cell research.
The degradation of dysfunctional proteins and organelles by autophagy is important for cell viability. Dikic and co-authors discuss how cargo selection is achieved during selective autophagy and how the processes involved in cargo delivery are related to membrane trafficking pathways.
Puisieux et al. discuss endothelial to mesenchymal transition (EMT)-inducing transcription factors in tumorigenesis. They explore how EMT contributes not only to tumour progression through its roles in invasion and metastasis, but also to malignant transformation and early tumour development by impinging on tumour suppressive pathways and cell differentiation states.
Multipolar spindles are a feature of cancer cells often associated with chromosomal aberrations. In the final Review in our Series on Genomic Instability, Logarinho and Maiato discuss how multipolar spindles form, with an emphasis on the role of the loss of spindle pole integrity in this process.
Repair of a chromosome break can result in part of a chromosome attaching to a different chromosome, causing gene deregulation and disease. Roukos and Misteli discuss the spatial aspect of chromosome translocation and the role of DNA repair pathways in this process.
In the second Review in our Genomic Instability series, Rudolph and colleagues discuss how the genomic damage that accumulates during ageing affects stem cell function through both cell-intrinsic and cell-extrinsic mechanisms.
