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Kofuji et al. demonstrate that upregulation of IMPDH2 promotes nucleostemin stabilization and nucleoli malformation, and its inactivation induces growth arrest in glioblastoma.
Boretto et al. demonstrate that organoids derived from patients with various types of endometrial pathologies can model disease traits and diversity, and can be used as a drug-screening tool.
Yeast cells segregate the old spindle pole body into the bud. Manzano-López et al. report that inverted segregation accelerates ageing due to aberrant partition of protein aggregates and damaged mitochondria.
Chen et al. provide an m5C landscape in bladder cancer and show m5C enrichment at oncogene mRNAs that promotes tumour progression. They identify YBX1 as the m5C ‘reader’ that recruits ELAVL1 to stabilize mRNAs.
AMPK and Parkin keep the necrosome in check. Lee et al. show that AMPK activates Parkin and prevents RIPK1−RIPK3 complex formation by promoting RIPK3 ubiquitination, thereby negatively regulating necroptosis, inflammation and tumour initiation.
Wu et al. demonstrate that HER2 recruits AKT1 to disrupt the STING signalosome, thereby suppressing damage-induced cellular senescence and STING-mediated antiviral and antitumour responses in vivo.
Sun et al. demonstrate that the development of bona fide liver cancer can be modelled at structural and molecular levels by introducing c-Myc into directly reprogrammed human hepatocytes with inactivated p53 and RB.
Senoo et al. show that, in response to chemoattractant stimulation, phosphorylated Rho–GDP in complex with Ras–GTP and mTORC2 promotes AKT phosphorylation to mediate cell migration.
Activating transcription factor 4 (ATF4) promotes MYC-driven tumour progression. Tameire et al. identify ATF4 and its target eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) as regulators of MYC-mediated amino acid biosynthesis and protein synthesis, thereby modulating tumour progression and survival in mice.
Janiszewska et al. show that minor subpopulations expressing IL11 and FIGF in breast cancer cells promote metastasis through altering local and systemic tumour microenvironments including neutrophils.
Tian et al. report that the chromatin-related factor Whsc1 regulates the exit from pluripotency and germ layer specification of mouse embryonic stem cells by binding to enhancers of mesendodermal regulators.
Sigal et al. report that Rspo3 regulates Lgr5 cells in the gastric gland base, induces their differentiation into secretory cells and stimulates epithelial antimicrobial defence against H. pylori infection.
Clancy et al. delineate a pathway for pre-miRNA delivery into nascent extracellular vesicles released from tumour cells and show that shed vesicles contain machinery allowing cell-free pre-miRNA processing.
Fu et al. report the transition of ESCs into a 2-cell-embyro-like state induced by Dux involves two steps and can be prevented by Myc and Dnmt1, which inhibit the downregulation of pluripotency genes and the activation of 2C+-upregulated elements.
Diring et al. identify ArhGAP12 and ArhGAP32 as RPEL proteins that bind G-actin. When bound to G-actin, ArhGAP12 cannot suppress Rac, thus coupling Rac activity to actin availability.
Gao, Nowak-Imialek, Chen et al. generate porcine and human stem cells that possess expanded developmental potency for both embryonic and extra-embryonic cell lineages.
Cleveland and colleagues report a DNA-replication-dependent error correction mechanism that acts in S phase to remove ectopically loaded CENP-A outside the centromeres, while retaining centromere-bound CENP-A.
Wang et al. map early cardiopharyngeal development in the chordate model Ciona and show that FGF–MAPK signalling maintains multipotency and promotes pharyngeal muscle fate, whereas Tbx1/10-Dach specify second heart lineage identity.
Demarco et al. demonstrate that a block in mitochondrial fusion leads to a loss of male germline stem cells in Drosophila, a disruption of lipid homeostasis and activation of TOR signalling.
Grainger et al. demonstrate that, in zebrafish and human cells, EGFR-mediated phosphorylation of Fzd9b promotes internalization of the Wnt9a–Fzd9b–LRP signalosome and subsequent signal transduction.