Volume 37 Issue 6, June 2019

Nitrogen use and root microbiota in rice

Hand-painted picture of a rice plant, showing the extensive root system. Zhang et al. show that rice recruits specific bacteria to the root microbiota to optimize nitrogen acquisition from soil.

See Zhang et al.

Image: Aili Li, Institute of Botany, Chinese Academy of Sciences, Beijing. Cover Design: Erin Dewalt.

Editorial

Mixing matters

Editorial 04 Jun 2019

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News

Appetite grows for biotech foods with health benefits

A new wave of bioengineered offerings is beginning to capture consumer interest.

Emily Waltz
News 29 Apr 2019
FBI raids Silicon Valley microbiome startup

News in Brief 04 Jun 2019
Around the world in a month

News in Brief 04 Jun 2019
Shake-up in AI drug discovery

News in Brief 04 Jun 2019
Drug makers chase anti-flu pill

Drug makers are targeting flu virus vulnerabilities to develop antivirals that not only stop infections in their tracks, but also temper emergence of drug resistance.

John Hodgson
News 12 May 2019
Charles River Labs hit by hackers

News in Brief 04 Jun 2019
Data Page
- Drug pipeline 1Q19
  
  Laura DeFrancesco
  Data Page 04 Jun 2019
News Feature
- Phage therapy’s latest makeover
  
  As issues of product consistency, standardization and specificity are being tackled, can phage therapeutics—long oversold and overhyped—finally realize their antibacterial potential?
  
  Charles Schmidt
  News Feature 08 May 2019

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Bioentrepreneur

Data Page
- Research biotech patenting 2018
  
  Brady Huggett
  Kathryn Paisner
  Bioentrepreneur Data Page 04 Jun 2019

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Correspondence

How bans on germline editing deprive patients with mitochondrial disease

I. Glenn Cohen
Eli Y. Adashi
Vardit Ravitsky
Correspondence 20 May 2019
The Kipoi repository accelerates community exchange and reuse of predictive models for genomics

Žiga Avsec
Roman Kreuzhuber
Julien Gagneur
Correspondence Open Access 28 May 2019

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Features

Nature Biotechnology’s academic spinouts of 2018

Our annual survey highlights startups taking on gene therapy, adoptive immune cell therapy, gene editing, and drugs targeting RNA modifications and the unfolded protein response. Ken Garber, Esther Landhuis, Melanie Senior, Cormac Sheridan and Laura DeFrancesco report.

Ken Garber
Esther Landhuis
Laura DeFrancesco
Feature 27 May 2019
Patents
- Worldwide CRISPR patent landscape shows strong geographical biases
  
  A survey of the CRISPR patent landscape shows the improvement of technology, a diversity of potential sectors of application, and a new geopolitical balance of forces in the field.
  
  Jacqueline Martin-Laffon
  Marcel Kuntz
  Agnès E. Ricroch
  Patents 04 Jun 2019
- Regenerative medicine
  
  Recent patents related to organoids, 3D culture and tissue engineering.
  
  Patents 04 Jun 2019

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News & Views

Mind the gap!

A simple chemical modification can substantially reduce the toxicity of antisense oligonucleotides.

Arthur M. Krieg
News & Views 10 May 2019
Show me the models

The Kipoi repository provides a home for trained machine-learning models that facilitates their sharing and reuse.

Casey S. Greene
News & Views 28 May 2019

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Research

Letters
- Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors
  
  Wider editing windows and different PAM requirements enable a broad set of genomic positions to be targeted with A and C base editors.
  
  Tony P. Huang
  Kevin T. Zhao
  David R. Liu
  
  Special:
  
  SCGE
  Letter 20 May 2019
Articles
- Taxonomic assignment of uncultivated prokaryotic virus genomes is enabled by gene-sharing networks
  
  Classification of archaeal and bacterial viruses can be automated with an algorithm that identifies relationships on the basis of shared gene content.
  
  Ho Bin Jang
  Benjamin Bolduc
  Matthew B. Sullivan
  Article 06 May 2019
- Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index
  
  Chemical modification of PS-ASO therapeutics reduces binding to cellular proteins and decreases toxic side-effects.
  
  Wen Shen
  Cheryl L. De Hoyos
  Stanley T. Crooke
  Article 29 Apr 2019
- Increasing the accuracy of nanopore DNA sequencing using a time-varying cross membrane voltage
  
  The accuracy of nanopore DNA sequencing is substantially improved by application of a variable-voltage sequencing mode.
  
  Matthew T. Noakes
  Henry Brinkerhoff
  Jens H. Gundlach
  Article 22 Apr 2019
- Increasing the specificity of CRISPR systems with engineered RNA secondary structures
  
  Changes to the secondary structure of the guide RNA enable substantial increases in specificity of Cas9 and Cas12 variants
  
  D. Dewran Kocak
  Eric A. Josephs
  Charles A. Gersbach
  Article 15 Apr 2019
- Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts
  
  A ribozyme-based circularization strategy improves the stability of exogenously expressed RNA aptamers.
  
  Jacob L. Litke
  Samie R. Jaffrey
  Article 08 Apr 2019
- NRT1.1B is associated with root microbiota composition and nitrogen use in field-grown rice
  
  Rice coordinates recruitment of the root microbiota to optimize nitrogen acquisition from soil.
  
  Jingying Zhang
  Yong-Xin Liu
  Yang Bai
  
  Collection:
  
  The plant microbiome
  Article 29 Apr 2019
Analysis
- Efficient integration of heterogeneous single-cell transcriptomes using Scanorama
  
  Scanorama integrates single-cell RNA-seq datasets from different tissues, different labs, different experiments or different technologies.
  
  Brian Hie
  Bryan Bryson
  Bonnie Berger
  Analysis 06 May 2019

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Amendments & Corrections

Publisher Correction: Phage therapy’s latest makeover

Charles Schmidt
Publisher Correction 21 May 2019
Author Correction: Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)

Rayner M. L. Queiroz
Tom Smith
Kathryn S. Lilley
Author Correction 23 May 2019

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Careers & Recruitment

Career Feature
- An effective matching method for a scientific mentoring program
  
  A questionnaire based on a popular personality assessment test contributes to the success of a new mentorship program.
  
  Juan Rivera-Mata
  Alejandro Martorell-Riera
  Career Feature 04 Jun 2019
People
- People
  
  A sample of goings-on in and around the biotech and pharmaceutical industry.
  
  People 04 Jun 2019

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Volume 37 Issue 6, June 2019

Nitrogen use and root microbiota in rice

Editorial

News

Data Page

News Feature

Bioentrepreneur

Data Page

Correspondence

Features

Patents

News & Views

Research

Letters

Articles

Analysis

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Careers & Recruitment

Career Feature

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