Volume 37 Issue 2, February 2019

The FDA approved record numbers of new molecular entities, orphan drugs, small-molecule generics and biosimilars in 2018. Could industry’s regulatory success of the past two years become the new normal?

Recent patents in siRNA, antisense oligonucleotides, and CRISPR.

Endogenous RNAs are edited using antisense oligos that recruit endogenous RNA-editing enzymes.

The treasure trove of disease resistance genes present in wild relatives of domesticated crops is rapidly discovered using association genetics and enrichment sequencing.

Cassava, a staple crop consumed by 800 million people, is enriched in iron and zinc through genetic biofortification.

The global set of bacterial and viral sequences can be rapidly searched using a data structure inspired by web-search algorithms.

A sensitive method to analyze metagenomes, CATCH, enables detection and characterization of diverse viral sequences, including the 356 viruses known to infect humans.

RNA-binding proteins can be identified and quantified in any organism using a simple method that combines UV cross-linking and phase separation.

A resource of >1,500 bacterial reference genomes sheds light on the human gut microbiome.

A large bacterial strain collection and genome sequences will boost gut microbiome research.

A quarterly snapshot of job expansions, reductions and availability in the biotech and pharma sectors.

A sample of goings on in and around the biotech and pharmaceutical industry.