This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Thomson, J.A. et al. Science 282, 1145–1147 (1998).
Reubinoff, B.E. et al. Nat. Biotechnol. 18, 399–404 (2000).
Mitalipova, M. et al. Stem Cells 21, 521–526 (2003).
Stojkovic, M. et al. Stem Cells 22, 790–797 (2004).
Cowan, C.A. et al. N. Engl. J. Med. 350, 1353–1356 (2004).
Amit, M. & Itskovitz-Eldor, J. J. Anat. 200, 225–232 (2002).
Carpenter, M.K. et al. Cloning Stem Cells 5, 79–88 (2003).
Rao, R.R. & Stice, S.L. Biol Reprod (2004).
Sato, N. et al. Dev Biol 260, 404–413 (2003).
Bhattacharya, B. et al. Blood (2003).
Acknowledgements
This work was supported in part by funding provided by the Georgia Tech/Emory Center (GTEC) for the Engineering of Living Tissues, an ERC Program of the National Science Foundation under award no. EEC-9731643. This work was also supported in part by funding from the National Institutes of Health (NIH-HL074303). We thank Bresagen Inc., for providing the hES cells used in this correspondence, and Roger Nielsen for assistance with real-time PCR analysis.
Author information
Authors and Affiliations
Corresponding author
Supplementary information
Supplementary Fig. 1
G-banded karyotype of BG01 hES cells at p42 (mechanical) + p23 (non-enzymatic)
Supplementary Fig. 2
Fluorescence in situ hybridization signal patterns for cell line BG02 p12 (mechanical) + p56 (enzymatic)
Supplementary Table 1
Fold change values for individual genes across three populations
Rights and permissions
About this article
Cite this article
Mitalipova, M., Rao, R., Hoyer, D. et al. Preserving the genetic integrity of human embryonic stem cells. Nat Biotechnol 23, 19–20 (2005). https://doi.org/10.1038/nbt0105-19
Published:
Issue Date:
DOI: https://doi.org/10.1038/nbt0105-19