Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 574 Issue 7778, 17 October 2019

Smoke signals

Cigarette smoking dramatically increases the risk of type 2 diabetes, but the mechanisms underlying this effect have remained elusive. In a paper in this issue, Paul Kenny and his colleagues reveal that, in rats, the transcription factor TCF7L2 mediates a signalling circuit that connects neurons in the brain activated by nicotine to blood-glucose regulation by the pancreas. The researchers show that when nicotine activates nicotine acetylcholine receptor (nAChR) proteins expressed on neurons in the medial habenula region of the brain, it also leads to adverse responses to nicotine that limit intake as well as to the release of glucagon and insulin by the pancreas. This in turn raises the levels of blood sugar, which is associated with a higher risk of developing diabetes. In addition, the raised levels of blood sugar create a feedback loop by inhibiting nAChRs expressed by medial habenula neurons, blocking adverse responses to smoking and so helping to establish nicotine dependence. TCF7L2 modulates the entire signalling circuit, thereby linking nicotine addiction with an increased risk of diabetes.

Cover image: Ian Tragen.

This Week

Top of page ⤴

News in Focus

Top of page ⤴

Comment

Top of page ⤴

Technology

  • Technology Feature

    • Genetically encoded voltage indicators change colour in real time when neurons transmit electrical information, offering unprecedented insight into neural activity.

      • Jyoti Madhusoodanan

      Collection:

      Technology Feature
Top of page ⤴

Careers

Top of page ⤴

Futures

Top of page ⤴

Research

Top of page ⤴

Amendments & Corrections

Top of page ⤴

Collections

  • How large national and international neuroscience programmes are creating new career opportunities for scientists of all disciplines.

    Spotlight
  • Two key drug approvals have re-energised the field after a period of uncertainty.

    Nature Outlook
Top of page ⤴
Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Quick links