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Volume 528 Issue 7583, 24 December 2015

The 2015 edition of Nature's 10 � a list of 10 people who mattered in science this year selected by Nature's team of editors � looks behind the major events and discoveries to the human endeavour that makes science work. This year's picks are UN climate chief Christiana Figueres, gene-editing pioneer Junjiu Huang, NASA Pluto specialist Alan Stern, chemical engineer Zhenan Bao, Iran's nuclear engineer/diplomat Ali Akbar Salehi, astronomer and defender of women's rights Joan Schmelz, population geneticist David Reich, superconductivity researcher Mikhail Eremets, synthetic biologist Christina Smolke, and the Reproducibility Project's Brian Nosek. Cover art: Peter Crowther

Editorial

  • The European Union has set a worrying trend by ignoring scientific advice on overfishing. It must put long-term sustainability plans ahead of short-term political gains.

    Editorial

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  • Physicists can better study the quantum behaviour of objects on the atomic scale.

    Editorial
  • Nature digs into the rumours about the effect of festive illuminations on wireless fidelity.

    Editorial
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World View

  • Rather than relying on far-off negative-emissions technologies, Paris needed to deliver a low-carbon road map for today, argues Kevin Anderson.

    • Kevin Anderson
    World View
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Research Highlights

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Social Selection

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Seven Days

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News

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News Feature

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Comment

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Books & Arts

  • Henry Nicholls talks to pioneering field biologist George Schaller — still studying iconic species at 82.

    • Henry Nicholls
    Books & Arts
  • Barbara Kiser reviews five of the week's best science picks.

    • Barbara Kiser
    Books & Arts
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Correspondence

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Obituary

  • Oil man who was first director of the United Nations Environment Programme.

    • Ehsan Masood
    Obituary
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News & Views

  • The cellular process of autophagy has been proposed to help kill Mycobacterium tuberculosis. But although the autophagy gene Atg5 is key to host immunity, other autophagy genes do not affect the outcome of tuberculosis. See Letter p.565

    • Samuel M. Behar
    • Eric H. Baehrecke
    News & Views
  • Microprocessor communications have received a boost from the integration of electronics and photonics in silicon — a first step towards low power consumption and efficient computing systems. See Letter p.534

    • Laurent Vivien
    News & Views
  • Machine learning, applied to complex multidimensional data, is shown to provide personalized dietary recommendations to control blood glucose levels. This is a step towards integrating the gut microbiome into personalized medicine.

    • Erica D. Sonnenburg
    • Justin L. Sonnenburg
    News & Views
  • Nanoscale particles have been uniformly dispersed in a magnesium alloy, yielding composites with record-breaking strengths — and raising the prospect of using magnesium as a lightweight metal for structural applications. See Letter p.539

    • Maria Teresa Pérez Prado
    • Carmen M. Cepeda-Jiménez
    News & Views
  • The discovery of microorganisms that can oxidize ammonia all the way to nitrate refutes the century-old paradigm that this nitrification process requires the activity of two types of microbe. See Article p.504 & Letter p.555

    • Marcel M. M. Kuypers
    News & Views
  • It emerges that innate immune cells called group 3 innate lymphoid cells signal directly to intestinal stem cells to promote the replacement of damaged epithelial cells lining the gut. See Letter p.560

    • Konrad Gronke
    • Andreas Diefenbach
    News & Views
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Article

  • WebNetwork analysis to determine the maximally bridged ring (or rings) of molecules is used as part of a strategy for the syntheses of architecturally complex natural chemicals; this strategy is demonstrated via the synthesis of the diterpenoid alkaloids weisaconitine D and liljestrandinine.

    • C. J. Marth
    • G. M. Gallego
    • R. Sarpong
    Article
  • The first genome-wide scan for selection using ancient DNA, based on data from 230 West Eurasians dating between to 6500 and 300 bc and including new data from 163 individuals among which are 26 Neolithic Anatolians, provides a direct view of selection on loci associated with diet, pigmentation and immunity.

    • Iain Mathieson
    • Iosif Lazaridis
    • David Reich
    Article
  • Until now, the oxidation steps necessary for complete nitrification have always been observed to occur in two separate microorganisms in a cross-feeding interaction; here, together with the study by van Kessel et al., Daims et al. report the enrichment and characterization of Nitrospira species that encode all of the enzymes necessary to catalyse complete nitrification, a phenotype referred to as “comammox” (for complete ammonia oxidation).

    • Holger Daims
    • Elena V. Lebedeva
    • Michael Wagner
    Article
  • A new deep proteomic analysis method is used to identify proteins that interact with wild-type cystic fibrosis transmembrane conductance regulator (CFTR) and its mutant version that is the major cause of cystic fibrosis.

    • Sandra Pankow
    • Casimir Bamberger
    • John R. Yates III
    Article
  • The ability of the DEAD-box RNA helicase DDX5 to interact with master transcription factor RORγt is dependent on binding of the long noncoding RNA Rmrp; the DDX5–RORγt complex coordinates transcription of selective TH17 genes and is required for the pathogenicity of TH17 cells.

    • Wendy Huang
    • Benjamin Thomas
    • Dan R. Littman
    Article
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Letter

  • Fast radio burst FRB 110523, discovered in archival data, reveals Faraday rotation and scattering that suggests dense magnetized plasma near the source; this means that to infer the source of the burst, models should involve young stellar populations such as magnetars.

    • Kiyoshi Masui
    • Hsiu-Hsien Lin
    • Jaswant K. Yadav
    Letter
  • Coronal mass ejections are driven by a sudden release of magnetic energy stored in flux ropes in the Sun’s corona, but when the ambient magnetic field that runs toroidally along an unstable flux rope is strong enough to prevent the flux rope from kinking, a dynamic magnetic tension force halts the eruption.

    • Clayton E. Myers
    • Masaaki Yamada
    • Edward E. DeLuca
    Letter
  • Matter-wave interferometers provide an opportunity to measure whether quantum superpositions exist at macroscopic length scales or only at microscopically small scales; now such instruments have demonstrated quantum interference of wave packets separated by 54 cm.

    • T. Kovachy
    • P. Asenbaum
    • M. A. Kasevich
    Letter
  • An electronic–photonic microprocessor chip manufactured using a conventional microelectronics foundry process is demonstrated; the chip contains 70 million transistors and 850 photonic components and directly uses light to communicate to other chips.

    • Chen Sun
    • Mark T. Wade
    • Vladimir M. Stojanović
    Letter
  • A textural examination of volcanic ash erupted from Santiaguito volcano in Guatemala coupled with an analysis of the geophysical signals indicates that rapid heating during fault friction can cause melting and vesiculation (development of bubbles) of hydrated silicic magma, thus strongly affecting magma strength and eruptive behaviour.

    • Yan Lavallée
    • Donald B. Dingwell
    • Gustavo Chigna
    Letter
  • Despite substantial evidence that neonicotinoid pesticides can have negative effects on bees, there have been no reports that this leads to problems with pollination; here bumblebee colonies exposed to a neonicotinoid are shown to provide reduced pollination services to apple trees, leading to a reduction in seed number.

    • Dara A. Stanley
    • Michael P. D. Garratt
    • Nigel E. Raine
    Letter
  • Until now, the oxidation steps necessary for complete nitrification had always been observed to occur in two separate microorganisms in a cross-feeding interaction; here, together with the study by Daims et al., van Kessel et al. report the enrichment and characterization of Nitrospira species that encode all of the enzymes necessary to catalyse complete nitrification, a phenotype referred to as ‘comammox’ (for complete ammonia oxidation).

    • Maartje A. H. J. van Kessel
    • Daan R. Speth
    • Sebastian Lücker
    Letter
  • Innate lymphoid cells increase the growth of mouse intestinal organoids via IL-22 production; recombinant IL-22 promotes growth of both mouse and human organoids, and promotes mouse intestinal stem cell (ISC) expansion and ISC-driven organoid growth via a STAT3-dependent pathway and independently of Paneth cells; IL-22 treatment in vivo enhances the recovery of ISCs from intestinal injury.

    • Caroline A. Lindemans
    • Marco Calafiore
    • Alan M. Hanash
    Letter
  • The relationship between DNA methylation and transcription factor binding was studied across the genome in mouse embryonic stem cells-the study reveals that the transcription factor NRF1 is methylation-sensitive and how physiological binding of NRF1 relies on local removal of DNA methylation.

    • Silvia Domcke
    • Anaïs Flore Bardet
    • Dirk Schübeler
    Letter
  • In this study, 83 proteins containing helix–loop–helix–loop repeats were designed—with sequences unrelated to known repeat proteins—and experimentally characterized; 43 solution X-ray scattering spectra and 15 structures of the designed proteins show that these non-natural repeat proteins have a broad range of curvatures and that their overall structures are in close agreement with design models.

    • TJ Brunette
    • Fabio Parmeggiani
    • David Baker
    Letter
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Feature

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Correction

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Futures

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Brief Communications Arising

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