Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A three-dimensional cell culture system has been developed that produces functioning pituitary tissue from mouse embryonic stem cells. The cells differentiate into layered structures, the development of which depends on close juxtaposition of two tissue types in formations that resemble local tissue reactions seen in vivo. Endocrine cells including corticotrophs and somatotrophs are produced. The corticotrophs efficiently secreted adrenocorticotropic hormone in response to corticotrophin releasing hormone, and transplantation of the pituitary tissues into a hypopituitary mouse model rescued a lethal deficiency in adrenocorticotropin. This work opens the possibility of developing regenerative therapies for pituitary defects, a major category of endocrinological disorders that includes empty sella syndrome, Sheehan syndrome and pituitary apoplexy. The cover image shows the developing mouse anterior pituitary expressing Pitx1 (red) at embryonic day 13, in contact with the neurohypophysis extending from the Rx+ hypothalamus (green).
Spain, Italy and Greece all have new governments and new research laws. Despite the pressures of economic austerity, investing in science now could bring disproportionate benefits.
The week in science: anti-HIV gel fails Africa trial; funding crunch for Global Fund to Fight AIDS, Tuberculosis and Malaria; and NASA’s Curiosity rover bound for Mars.
Materials that refract light backwards are thought to be required for making super-resolution lenses. An alternative proposal — that conventional, positively refracting media can do the job — has met with controversy. Two experts from either side of the debate lay out their views on the matter.
The expensive-tissue hypothesis proposes that brain enlargement during human evolution was offset by a reduced gut size. The finding that the typical trade-off in mammals is between brain size and fat reserves suggests otherwise. See Letter p.91
It is difficult to recapitulate organ development in vitro, especially when interactions between tissues are essential. Nonetheless, researchers have now achieved this for the pituitary gland. See Article p.57
Regulation of body temperature by the nervous system is essential for physiological function in both health and disease. The immune system also seems to have a crucial role in this process. See Letter p.104
The population of γ-ray bursts is sometimes enriched by perplexing events that challenge established theoretical models. Two teams get to grips with understanding one such event — the 'Christmas' burst. See Letters p.69 & p.72
A study of cerium in zircon minerals has allowed an assessment of the redox conditions that prevailed when Earth's earliest magmas formed. The results suggest that the mantle became oxidized sooner than had been thought. See Letter p.79
The mutations that underlie the diseases tuberous sclerosis complex and fragile X syndrome produce abnormalities in synaptic plasticity and function that can be corrected by treatments that modulate metabotropic glutamate receptor 5 in opposite directions.
Observation of a many-body pairing gap in a trapped, 2D atomic Fermi gas shows that ultracold atomic gases can be used to emulate the physics of correlated 2D superconductors, with the ultimate goal of understanding high-temperature superconductivity.
Earth's mantle is likely to have reached its present-day oxidation state before 4 billion years ago, according to a determination of the oxidation state of Hadean magmatic melts.
Exposure to cold drives IL-4-mediated alternative macrophage activation and catecholamine secretion in brown and white adipose tissues to stimulate thermogenesis.
The Src family kinase Lyn is identified as a physiological redox sensor that mediates the initial attraction of leukocytes to wounds in zebrafish larvae.