Nanoparticles that generate light through a mechanism known as second harmonic generation have been used to image live tissue. The particles overcome many problems associated with fluorescent probes for bioimaging.
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Cohen, B. Beyond fluorescence. Nature 467, 407–408 (2010). https://doi.org/10.1038/467407a
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DOI: https://doi.org/10.1038/467407a
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