Where would you start in trying to work out the structure of a macromolecular machine consisting of 456 proteins? Taking a combined experimental and computational approach is one answer.
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Aitchison, J., Wozniak, R. Pore puzzle. Nature 450, 621–622 (2007). https://doi.org/10.1038/450621a
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DOI: https://doi.org/10.1038/450621a