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Topobiologically complex mini-colons—which enable the faithful in vitro recapitulation of colorectal cancer tumorigenesis and its environmental determinants—offer the possibility to reduce animal use in a wide range of experimental applications.
We develop an optical method that can set and read the state of electrons in the valley polarization of bulk transition metal dichalcogenide semiconductors, with potential utility as digital storage at quantum coherent timescales and application in quantum computing.
Rhodium catalysts confined in zeolite pores exhibit high regioselectivity in the hydroformylation process of propene to high-value n-butanal, surpassing the performance of all heterogeneous and most homogeneous catalysts developed so far.
Using complementary multiplicity-edited 13C nuclear magnetic resonance spectra, oxidative dearomatization is shown to be a key driver for generating structural diversity during processing of dissolved organic matter and the data also suggest high abundance of OCqC3 units.
Patagia—the mammalian gliding membrane—repeatedly originated through a process of convergent genomic evolution, whereby the regulation of Emx2 was altered by distinct cis-regulatory elements in independently evolved species.
Phylogenomic analysis of 7,923 angiosperm species using a standardized set of 353 nuclear genes produced an angiosperm tree of life dated with 200 fossil calibrations, providing key insights into evolutionary relationships and diversification.
Sea-based optical clocks combining a molecular iodine spectrometer, fibre frequency comb and electronics for monitoring and control demonstrate high precision in a smaller volume than active hydrogen masers.
Prostaglandin E2 from the tumour microenvironment impairs interleukin-2 sensing by tumour-infiltrating lymphocytes, restricting proliferative response and promoting T cell death via metabolic impairment and ferroptosis.
Analysis of ancient DNA from 424 individuals in the Avar period, from the sixth to the ninth century AD, reveals population movement from the steppe and the prolonged existence of a steppe nomadic descent system centred around patrilineality and female exogamy in central Europe.
A highly precise timekeeping instrument has been adapted for the real world. The compact and robust device is smaller than its commercial counterparts and performs comparably in the laboratory and aboard a naval ship.
A therapeutic strategy that alters gene expression in a rare and severe neurodevelopmental condition has been tested in stem-cell-based models of the disease, and has been shown to correct genetic and cellular defects.
Cells grown on a 3D scaffold have generated a ‘mini-colon’ that mimics key features of the organ. Controlled expression of cancer-associated genes in the system offers a way to examine tumour formation over space and time.