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Serum antibody responses to sequential homologous booster vaccines derive overwhelmingly from primary cohort B cells at the expense of de novo responses; this ‘primary addiction’ can be overcome by boosting with variant antigens.
Findings from large-scale studies in Sweden and the USA indicate that providing financial incentives for vaccination and informing about state incentive programmes do not have any negative unintended consequences.
Theoretical and experimental analysis of the effect of grain shape in bed load sediment transport is performed and a shape-corrected sediment transport law that provides greater accuracy in predictions is proposed.
Comparisons of a chimeric recombinant version of SARS-CoV-2, the ancestral SARS-CoV-2 strain and an Omicron isolate show that the attenuated virulence of Omicron is caused by mutations in both the spike protein and nsp6.
A three-dimensional metal–organic framework reversibly binds ammonia by cooperative insertion into its metal–linker bonds to form a dense, one-dimensional coordination polymer, enabling high-capacity ammonia uptake with intrinsic thermal management.
γδ T cells contribute to the response to immune checkpoint blockade treatment in patients with HLA-class-I-negative DNA mismatch repair-deficient colon cancers. .
Analysis of a continuous record of water-isotope ratios from the West Antarctic Ice Sheet Divide ice core reveals a dominant role for annual maximum insolation in determining West Antarctic summer temperature during the Holocene.
Analyses of in-frame stop codons in protein-coding genes of Blastocrithidia nonstop with all three stop codons reassigned reveal a mechanism for UGA reassignment in eukaryotes involving shortening of the tRNA anticodon stem and a mutant eRF1 release factor.
An electrically driven motor on the molecular scale based on [3]catenane is described, in which two cyclobis(paraquat-p-phenylene) rings operate by means of redox reactions, demonstrating highly unidirectional movement around a circular loop.
Accurate measurements of the antineutrino energy spectrum of 235U fission by the STEREO detector reject the sterile neutrino hypothesis and point to biases in the nuclear data to explain the discrepancies with the prediction.
The authors measure elastic p-wave interaction energies in pairs of fermionic atoms occupying the lowest two orbitals of an optical lattice; isolation of individual pairs of atoms protects against three-body recombination, enabling a theoretical maximum of interaction energy to be achieved.
Analysis of the kinase activity of 300 protein Ser/Thr kinases reveals that the substrate specificity of the kinome is substantially more diverse than expected and is driven extensively by negative selectivity
The electrical contact of two-dimensional transistors is pushed close to the quantum limit by hybridization of the energy bands with antimony; the contacts have low contact resistance and excellent stability.
The authors model the creep of MgO periclase at lower mantle pressures and temperatures, finding that it deforms more slowly than bridgmanite at mantle strain rate.
Placing monolayer tungsten diselenide on Bernal-stacked bilayer graphene promotes enhanced superconductivity, indicating that proximity-induced spin–orbit coupling plays a key role in stabilizing the pairing, paving the way for engineering tunable, ultra-clean graphene-based superconductors.
Structural studies of Escherichia coli transcription intrinsic termination complexes representing distinct intermediates using cryo-electron microscopy provide insights into the steps and mechanism of transcription termination.
Time-series observations from the JWST of the transiting exoplanet WASP-39b show gaseous water in the planet’s atmosphere and place an upper limit on the abundance of methane.
Two signals identified in short gamma-ray bursts from archival Burst and Transient Source Experiment data show kilohertz quasiperiodic oscillations, implying the ringing of a hypermassive neutron star before collapsing to a black hole.
