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Restructure data-gathering and evaluation networks to address climate change, energy, food, health and water provision, say Yonglong Lu and colleagues.
To get targeted treatments to more cancer patients pair genomic data with clinical data, and make the information widely accessible, urges Mark A. Rubin.
Twenty-five years after launch, the wild success of the space telescope argues for a new era of bold exploration in the face of tight budgets, says Mario Livio.
Biological data will continue to pile up unless those who analyse it are recognized as creative collaborators in need of career paths, says Jeffrey Chang.
Agree what is needed, look for leaders with fire in their belly and emotional intelligence, and support them, advise Pierre-Alain Clavien and Joseph Deiss.
Meeting global food needs requires strategies for storing rainwater and retaining soil moisture to bridge dry spells, urge Johan Rockström and Malin Falkenmark.
Corruption is a barrier to innovation, warns Alina Mungiu-Pippidi. Greater scrutiny of public spending is needed if science and technology are to fulfil their potential.
To save millions of dollars and dramatically improve reproducibility, protein-binding reagents must be defined by their sequences and produced as recombinant proteins, say Andrew Bradbury, Andreas Plückthun and 110 co-signatories.