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Artificial intelligence control is used to avoid the emergence of disruptive tearing instabilities in the magnetically confined fusion plasma in the DIII-D tokamak reactor.
The demethylase KDM5C, mutations in which often lead to intellectual disability, is identified as a crucial player in regulating the precise timing of neurodevelopment together with the WNT signalling pathway.
A modelling analysis shows that an unusually long gamma-ray burst gave rise to a lanthanide-rich kilonova following the merger of a neutron star–neutron star or of a neutron star–black hole.
Attachment of the ubiquitin-like modifier UFM1 to 60S ribosomes has a critical function in the release and recycling of stalled or terminated ribosomes from the endoplasmic reticulum membrane.
The immune system is tolerized against the neuromyelitis optica autoantigen AQP4 by thymic B cells, which present their endogenous AQP4 to AQP4-reactive thymocytes.
IL-10 exerts its anti-inflammatory activity in macrophages by increasing the expression of enzymes that promote fatty acid desaturation and downstream regulation of the transcription factor REL.
An experimental design consisting of a photonic-crystal nanoslab covered with upconversion nanoparticles demonstrates the phenomenon of supercritical coupling, resulting in giant enhancement of upconversion by photonic bound states in the continuum.
Spatial and kinematic analysis of the solar neighbourhood shows that the Radcliffe Wave, a wave-shaped chain of star-forming gas clouds, is oscillating through the Galactic plane while also drifting radially away from the Galactic Centre.
A meta-analysis of genome-wide association studies of type 2 diabetes (T2D) identifies more than 600 T2D-associated loci; integrating physiological trait and single-cell chromatin accessibility data at these loci sheds light on heterogeneity within the T2D phenotype.
A study describes the release of clinical-grade whole-genome sequence data for 245,388 diverse participants by the All of Us Research Program and characterizes the properties of the dataset.
In neutrophil progenitor cells, stopping the process of loop extrusion by depleting nipped-B-like protein (NIPBL) results in the assembly of polymorphonuclear structures and the activation of a neutrophil-specific gene program.
A study identifies a new bacterial ribosome hibernation factor, Balon, and describes its association with EF-Tu and its initiation of mRNA-independent hibernation during protein synthesis.
The cryo-electron microscopy structure of the human phagocyte NADPH oxidase in the activated state provides insight into how cytosolic factors bind to and promote the activating conformational changes of NOX2, facilitating its efficient electron transfer.
Behavioural tracking and wireless neural and eye-tracking recordings show that freely moving macaques learn to cooprate using visually guided signals along the visual-frontal cortical network.
Ultrafast time-resolved serial femtosecond crystallography is used to investigate a photodissociation reaction in a protein, revealing the strong impact of the pump laser fluence on the structural changes and the reaction mechanism.
We find that gender bias is more prevalent in images than text, that the underrepresentation of women online is substantially worse in images and that googling for images amplifies gender bias in a person’s beliefs.
Examining the in-plane spin components of the noncoplanar antiferromagnet manganese ditelluride provides spectroscopic and computational evidence of materials with a new type of plaid-like spin splitting in the antiferromagnetic ground state.
