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A study of calcium homeostasis in the plant Arabidopsis reveals two signalling pathways it uses to balance the objectives of growth and immunity by regulating the level of Ca2+ in the cytosol.
Spontaneous liquid–liquid phase-separation behaviour of high-aspect-ratio fibrils, obtained from supramolecular polymerizations of synthetic components, forms tactoids by means of an entropy-driven pathway.
Newly developed microfluidic neural tube-like and forebrain-like structures based on human pluripotent stem cells can model pivotal aspects of neural patterning along both the rostral–caudal and dorsal–ventral axes.
Pinning-point changes over three epochs spanning the periods 1973–1989, 1989–2000 and 2000−2022 were measured, and by proxy the changes to ice-shelf thickness back to 1973–1989 were inferred.
Models show that human cooperation cannot evolve reliably under repeated interactions or under intergroup competitions, but combining the two mechanisms predicts a distinctive strategy, observed experimentally in Papua New Guinea, in which individuals exhibit cooperative reciprocity with ingroup partners and uncooperative reciprocity with outgroup partners.
Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.
Integer and fractional quantum anomalous Hall effects in a rhombohedral pentalayer graphene–hBN moiré superlattice are observed, providing an ideal platform for exploring charge fractionalization and (non-Abelian) anyonic braiding at zero magnetic field.
The mechanisms of action and resistance of valemetostat, an EZH1–EZH2 dual inhibitor, in patients with adult T cell leukaemia/lymphoma who initially responded but later showed disease progression are explored.
A silicon-based electrode system is described that allows tunable spatiotemporal photostimulation of cardiac systems, with the optoelectronic capabilities of these devices being demonstrated in mouse, rat and pig heart models.
Studies of vocal production in baleen whales show that their larynx has evolved unique structures that enable their low-frequency vocalizations but limit their active communication range.
A study presents a technique to sandwich 3D perovskite with 2D perovskites at the top and bottom, improving the performance and stability of perovskite solar cells.
A study reports that the Theoris anti-phage defence system is activated through helical filament assembly of the ThsA effector and details the activation mechanism.
Optical nanoscale disk memory with petabit-level capacity is developed by extending the recording architecture to three dimensions with hundreds of layers, and exabit-level storage can be achieved by stacking the disks into arrays.
Using viral sequence data, individuals with persistent SARS-CoV-2 infections were identified, and had higher odds of self-reporting long COVID, in a large community surveillance study.
A germanium–silicon single-photon avalanche diode operated at room temperature shows a noise-equivalent power improvement over the previous Ge-based single-photon avalanche diodes by 2–3.5 orders of magnitude.
A bulk ceramic composed of interlocked boron nitride nanoplates with a laminated structure of twist-stacked nanoslices is created using hot-pressing and spark plasma sintering, which exhibits large elastic and plastic deformability and high strength at room temperature.
Excitatory pyramidal neurons preferentially target inhibitory interneurons with the same selectivity and, in turn, inhibitory interneurons preferentially target pyramidal neurons with opposite selectivity, forming an opponent inhibition motif that supports decision-making.
Artificial intelligence control is used to avoid the emergence of disruptive tearing instabilities in the magnetically confined fusion plasma in the DIII-D tokamak reactor.
