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Radiopharmaceuticals engineered with click chemistry to selectively bind to tumour-specific proteins can be used to successfully target tumour cells, boosting the pharmacokinetics of radionuclide therapy and improving tumour regression.
The accretion disk from a star tidally disrupted by a supermassive black hole undergoes Lense–Thirring precession with strong, quasi-periodic X-ray flux and temperature modulations.
Experiments using fentanyl treatment of mice show that µ-opioid receptors mediate positive reinforcement in the ventral tegmental area and negative reinforcement in central amygdala, thereby identifying the circuits that lead to opioid addiction.
A study shows that implants with an adhesive implant–tissue interface mitigate the formation of a fibrous capsule when attached to various organs in mice, rats and pigs.
Screening in Escherichia coli and biochemical experiments show that in Arabidopsis thaliana, OSCA2.1 and OSCA2.2 function as plant sensors of hypo-osmolarity, utilize Ca2+ oscillations as second messengers and have crucial roles in pollen germination.
The use of computational crystal-structure prediction has enabled the targeted assembly of frameworks of porous organic ammonium halide salts that have many of the qualities of metal–organic frameworks despite containing no metal.
Time-resolved photoelectron circular dichroism with a temporal resolution of 2.9 fs is used to track the ultrafast electron dynamics following ultraviolet excitation of neutral chiral molecules, which generate chiral currents that exhibit periodic rotation direction reversal.
Cryo-electron microscopy structures of cross-exon pre-B and B-like complexes contribute new insights into the molecular mechanisms that mediate the switch from a cross-exon to a cross-intron organized spliceosome.
Prov-GigaPath, a whole-slide pathology foundation model pretrained on a large dataset containing around 1.3 billion pathology images, attains state-of-the-art performance in cancer classification and pathomics tasks.
Atomic-resolution imaging of the surface structure of hexagonal water ice is achieved using cryogenic atomic force microscopy, providing a molecular perspective on the origin and mechanism of of ice premelting.
Single-cell RNA sequencing and 3D imaging have revealed the cellular changes and structural reorganization that occur during the progression of human chronic liver disease and as the liver attempts to regenerate.
Stable chelation of the 147Pm radionuclide in aqueous solution by the newly synthesized organic diglycolamide ligand is demonstrated and the resulting complex studied, showing accelerated shortening of bonds at the beginning of the lanthanide series.
Microballistic impact testing at strain rates greater than 106 s−1 shows that pure metals, including copper, gold and titanium, become stronger with increasing temperature.
We develop a low-temperature, damage-free process using van der Waals lamination to integrate multiple circuit tiers into a monolithic three-dimensional device, incorporating unique multi-tier functionality and resolving legacy issues with the layering technology.
Recovered cement paste can be reclinkered if used as a partial substitute for the lime–dolomite flux used in steel recycling, which can reduce waste and carbon emissions.
An antibody–drug conjugate that targets the pan-haematopoietic marker CD45 combined with transplanted stem cells engineered to be shielded from it can eradicate leukaemic cells while preserving haematopoiesis.
Structures of the kainate receptor GluK2 with and without concanavilin A and BPAM344 show how these ligands modulate channel activity and reveal the molecular basis of kainate receptor gating.
Structural analysis of the human choline and ethanolamine transporters FLVCR1 and FLVCR2 clarifies the mechanisms of transport, the conformational dynamics of these proteins and the disease-associated mutations that interfere with these processes.
Stretchable radio-frequency electronics based on a dielectro-elastic elastomer is demonstrated to be capable of completely maintaining operating frequencies unaffected by strain and shows superior electrical, mechanical and thermal properties compared with conventional stretchable substrate materials.
