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A study reveals that most transcripts in Mycobacterium tuberculosis are incomplete, likely because of the tendency of the transcription machinery in this species to pause on genomic DNA.
The effect of the latitudinal diversity gradient on plants on oceanic islands is weakened by classical abiotic physical drivers of island biogeography and, to a greater extent, by mutualism with other species.
Experiments in mice show that designed epigenome editors that contain domains of transcriptional repressors can enable stable epigenetic silencing of Pcsk9, a gene with a role in cholesterol homeostasis, without inducing DNA breaks.
An analysis of tree survival data from forest sites worldwide shows that in the tropics, rare tree species experience stronger stabilizing density dependence than common species, wheras no correlation of stabilizing density dependence and abundance exists in the temperate zone.
Incomplete duplication of the C-rich telomeric repeat strand by lagging-strand DNA synthesis is counteracted by DNA synthesis mediated by CST–polymerase α-primase.
Bandit optimization models are used to identify generally applicable conditions by efficient condition sampling and evaluation of experimental feedback.
In order to explore superconductivity in hydride materials, local magnetometry inside a diamond anvil cell is performed with sub-micron spatial resolution at megabar pressures using nitrogen-vacancy colour centres.
An electrolyte design using small-sized fluoroacetonitrile solvents to form a ligand channel produces lithium-ion batteries simultaneously achieving high energy density, fast charging and wide operating temperature range, desirable features for batteries working in extreme conditions.
Analyses of single epithelial cells from early-stage lung adenocarcinoma and normal lung identifies a population of intermediate cells that may have an increased likelihood of transforming to tumour cells after injury such as tobacco exposure.
Audio and visual stimulation at 40 Hz promote cerebrospinal and interstitial fluid flux in mouse brain and result in amyloid clearance via the glymphatic system in a mouse model of Alzheimer’s disease.
We successfully rebuild an approximate void-free additive manufacturing microstructure in Ti-6Al-4V titanium alloy by the development of a void-free additive manufacturing processing technique through an understanding of the asynchronism of phase transformation and grain growth.
Transcriptomic and chromatin accessibility analyses of naive and transplanted colon cancer organoids in a mouse model reveal a key role for the transcription factor SOX17 in establishing a permissive immune environment for tumour cells.
An analysis of eight ultra-faint galaxies during the epoch of reionization with absolute magnitudes between −17 mag and −15 mag shows that most of the photons that reionized the Universe come from dwarf galaxies.
Stress release at stepped platinum surfaces is shown to influence the strain experienced by atoms near the steps, resulting in effects on the catalytic activity of the whole surface.
An insertion of an Alu element into an intron of the TBXT gene is identified as a genetic mechanism of tail-loss evolution in humans and apes, with implications for human health today.
A study provides evidence for a shared lymphatic circuit that connects the posterior eye and the brain, allowing the generation of immune responses to protect the CNS against pathogens and tumours following intravitreal immunization.
In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.