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Analyses of single epithelial cells from early-stage lung adenocarcinoma and normal lung identifies a population of intermediate cells that may have an increased likelihood of transforming to tumour cells after injury such as tobacco exposure.
Audio and visual stimulation at 40 Hz promote cerebrospinal and interstitial fluid flux in mouse brain and result in amyloid clearance via the glymphatic system in a mouse model of Alzheimer’s disease.
We successfully rebuild an approximate void-free additive manufacturing microstructure in Ti-6Al-4V titanium alloy by the development of a void-free additive manufacturing processing technique through an understanding of the asynchronism of phase transformation and grain growth.
Transcriptomic and chromatin accessibility analyses of naive and transplanted colon cancer organoids in a mouse model reveal a key role for the transcription factor SOX17 in establishing a permissive immune environment for tumour cells.
An analysis of eight ultra-faint galaxies during the epoch of reionization with absolute magnitudes between −17 mag and −15 mag shows that most of the photons that reionized the Universe come from dwarf galaxies.
Stress release at stepped platinum surfaces is shown to influence the strain experienced by atoms near the steps, resulting in effects on the catalytic activity of the whole surface.
An insertion of an Alu element into an intron of the TBXT gene is identified as a genetic mechanism of tail-loss evolution in humans and apes, with implications for human health today.
A study provides evidence for a shared lymphatic circuit that connects the posterior eye and the brain, allowing the generation of immune responses to protect the CNS against pathogens and tumours following intravitreal immunization.
In mice, a population of astrocytes in the central striatum, characterized by expression of μ-crystallin, has a role in perseveration phenotypes that are often associated with human neuropsychiatric disorders.
Dimorphos ejecta plume properties were revealed by the observations from the LICIACube cube satellite, which was deployed 15 days in advance of the impact of DART.
A study of calcium homeostasis in the plant Arabidopsis reveals two signalling pathways it uses to balance the objectives of growth and immunity by regulating the level of Ca2+ in the cytosol.
Spontaneous liquid–liquid phase-separation behaviour of high-aspect-ratio fibrils, obtained from supramolecular polymerizations of synthetic components, forms tactoids by means of an entropy-driven pathway.
Newly developed microfluidic neural tube-like and forebrain-like structures based on human pluripotent stem cells can model pivotal aspects of neural patterning along both the rostral–caudal and dorsal–ventral axes.
Pinning-point changes over three epochs spanning the periods 1973–1989, 1989–2000 and 2000−2022 were measured, and by proxy the changes to ice-shelf thickness back to 1973–1989 were inferred.
Models show that human cooperation cannot evolve reliably under repeated interactions or under intergroup competitions, but combining the two mechanisms predicts a distinctive strategy, observed experimentally in Papua New Guinea, in which individuals exhibit cooperative reciprocity with ingroup partners and uncooperative reciprocity with outgroup partners.
Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.
Integer and fractional quantum anomalous Hall effects in a rhombohedral pentalayer graphene–hBN moiré superlattice are observed, providing an ideal platform for exploring charge fractionalization and (non-Abelian) anyonic braiding at zero magnetic field.
The mechanisms of action and resistance of valemetostat, an EZH1–EZH2 dual inhibitor, in patients with adult T cell leukaemia/lymphoma who initially responded but later showed disease progression are explored.
A silicon-based electrode system is described that allows tunable spatiotemporal photostimulation of cardiac systems, with the optoelectronic capabilities of these devices being demonstrated in mouse, rat and pig heart models.
