Wei et al. identify the HDL receptor SR-B1 as a host factor that enhances the infection of cultured cells with SARS-CoV-2 in the presence of ACE2.

See Wei et al.

Failure to import pyruvate into the mitochondria of cardiomyocytes results in metabolic maladaptation, cardiac hypertrophy and heart failure, thus underscoring the central role of pyruvate metabolism in heart function.

See Fernandez-Caggiano et al.

Yu et al. report a preparation that enables transplantation of pancreatic islets (pictured) underneath the skin and achieves long-term euglycaemia in several preclinical models of type 1 diabetes, thus providing a simple method that might enable a more widespread adoption of islet transplantation in the clinic.

See Yu et al.

Our September issue includes a Focus on exercise metabolism and health, consisting of Reviews, Comments and research Articles revisiting foundational topics and highlighting new paradigms in exercise and muscle metabolism, as well as their broader implications for organismal health.

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Legouis et al. demonstrate that impaired glucose synthesis in the renal proximal tubules during acute kidney injury leads to metabolic abnormalities and is associated with mortality.

See Legouis et al.

An artificial intelligence (AI)-based decision support system provides weekly insulin dosage recommendations to patients with type 1 diabetes (T1D) and, according to analysis of previously collected patient data, exhibits high agreement with dosage recommendations from physicians.

See Tyler et al.

Tellez et al. generate an immunocompromised mouse model that lacks glucagon and use it to study transplanted human islets from people with or without diabetes, thus providing insight into human α-cell function.

See Tellez et al.

Human kidneys filter 180 litres of fluid from plasma per day, with almost complete retention of albumin and other macromolecules. Here, the authors used ultraresolution microscopy together with mathematical modelling to provide an experimentally validated model of the kidney filtration barrier.

See Butt et al.

Hypothalamic neuronal populations with sexually dimorphic gene expression and functions maintain energy homeostasis by controlling locomotory activity and thermogenesis in a sex-specific manner.

See van Veen et al.

Microbial DNA signatures are detected in the liver, the serum and three different adipose tissues (subcutaneous, mesenteric and omental fat) of people undergoing weight-loss surgery. In mesenteric fat, these signatures differ between individuals with normoglycaemia versus type 2 diabetes.

See Anhê et al.

Hartl et al. demonstrate how metabolism and the cell cycle are coupled in Caulobacter crescentus. Approximately 14% of the measured metabolites change during the cell cycle, and fluctuations in glutathione levels are required for coordinated cell division.

See Hartl et al.

Mechanosensing affects pancreatic cancer cell migration, metabolism and metastatic potential by targeting the creatine–phosphagen ATP-recycling system.

See Papalazarou et al.