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Gao et al. devise a global metabolic rewiring approach to overcome methanol toxicity and use it as sole substrate for enhanced free fatty acid production in yeast, which may then be beneficial for global carbon neutrality.
Ultraviolet exposure on the skin promotes food intake and body weight gain in males, but not females, by increasing ghrelin expression in skin adipocytes.
Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which is shown to be regulated by the transcription factor C/EBPδ and the DNA methylation eraser TET3.
Anti-PD-1 immunotherapy often leads to undesired side effects such as colitis. In this study, Wu, Hu, Han et al. report a metabolic reconfiguration in colonic lymphoid tissue inducer (LTi) cells regulated by PD-1 signaling that modulates inflammatory states in the gut.
Hypothalamic AgRP neurons are shown to control peripheral and central levels of lysophospholipids in association with food deprivation, which leads to cortical excitability, hyperphagia and body weight gain.
Targeting extracellular matrix (ECM) remodelling is a feasible avenue to prevent cancer aggressiveness and metastasis. In this study, Kay et al. show that metabolic flux in cancer-associated fibroblasts is coupled to enhanced proline synthesis by PYCR1 to support elevated production of collagen-rich ECM, thus contributing to cancer spreading.
Sugimoto et al. show that maresin 2, a specialized pro-resolving mediator that is secreted from brown adipose tissue upon cold exposure, contributes to amelioration of obesity-induced inflammation.
Li et al. show how mitochondrial content is regulated when oxygen is depleted, as well as how this process is impaired in cancer types related to the von Hippel–Lindau syndrome.
Hu and Zhao et al. identify a mechanism mediated by CCL18 and RFX5, through which tissue macrophages adapt their metabolic programme to nutrient stress in the context of autoimmune diseases.
Production of oxidized biomass is necessary to support cancer cell proliferation. In this work, Li et al. provide a quantitative analysis of the cellular needs and biochemical bottlenecks in lipid biosynthesis arising from the requirement to regenerate the cofactor NAD+.
In this work, using a combination of metabolomics and CRISPR-based genetic screens, Garcia-Bermudez, Badgley, Prasad et al. show that pancreatic cancer cells overcome aspartate limitation in hypoxia by upregulating macropinocytosis.
In this work, Danileviciute, Zeng et al. provide new insights into the regulation of the PDH complex by PARK7/DJ-1 and show its relevance in Treg homeostasis during ageing.
Liu et al. show that the non-oxidative pentose phosphate pathway is crucial for maintaining regulatory T cell (Treg) function, as deletion of transketolase in Treg cells results in loss of immune tolerance in mice.
Geng et al. show that β-klotho, an FGF21 co-receptor, can act independently of FGF21 to promote glycolysis and glucose-stimulated insulin secretion in pancreatic β-cells via the cytokine receptor GP130-mediated signaling pathway.
In this study, Cheng et al. show that ammonia released from glutaminolysis disrupts the SCAP–Insig association, thus activating SREBP-1 and promoting lipogenesis to support tumour growth
Ameroso et al. reveal a role for astrocytic brain-derived neurotrophic factor in the hypothalamus for regulating whole body energy homeostasis by means of TrkB.T1 receptor signaling.
Different gut bacteria have been shown to promote colorectal cancer (CRC) progression. The authors identify formate as an oncometabolite derived from Fusobacterium nucleatum, which promotes CRC formation by increasing cancer stemness.
Ampomah et al. show that apoptotic cell-derived methionine taken up by macrophages during efferocytosis plays a role in mediating tissue resolution by providing a substrate for DNA methylation and repression of the ERK1/2 phosphatase Dusp4, causing activation of ERK1/2 and expression of pro-resolving mediators