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Piccolo and colleagues discuss the current knowledge on YAP/TAZ biology in cancer, highlighting recent progress in the field and discussing open questions, as well as potential clinical implications.
Schmatko et al. review the application of artificial intelligence to digitized histopathology for cancer diagnosis, prognosis and classification and discuss its potential utility in the clinic and broader implications for cancer research and care.
Brody and colleagues discuss the current status and potential of cancer vaccines, highlighting challenges and opportunities to advance promising candidates to the clinic.
Lavie et al. review the recent advances in the field of cancer-associated fibroblasts, including their tissue-specific complexity and overall plasticity, as revealed by single-cell technologies.
Melero and colleagues discuss the current landscape of immunotherapy combinations, ongoing clinical studies and the translational implications for efficacy and safety across tumor types.
Stanley and Abdel-Wahab review the latest insights into the biological mechanisms of RNA splicing dysregulation in cancer and the emerging landscape of therapeutic opportunities in this field.
Llovet and colleagues review recent advances in hepatocellular carcinoma therapy and the clinical workflows for the selection and monitoring of patients undergoing systemic therapies and immunotherapy.
Hosein et al. discuss the current therapeutic landscape in pancreatic cancer as well as the translational and clinical implications and the challenges to overcome.
Hwang and colleagues discuss recent advances and current challenges in developing immunotherapies for pediatric brain cancer, as well as the clinical implications of ongoing and completed studies.