Volume 5 Issue 9, September 2021

Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel

This issue highlights drug-delivery strategies and technologies, from nanoscale delivery systems to implantable biomaterial drug depots to microneedle arrays, for a number of biomedical applications in ophthalmology, oncology, endocrinology, immunology, rheumatology, anaesthesiology and treating infectious diseases.

The cover illustrates that self-assembled nanofibres carrying site-1 sodium channel blockers and designed to mimic specific interactions of the blockers with peptide sequences on voltage-gated sodium channels led to prolonged nerve blockade with low systemic toxicity in rats.

SeeArticle Ji et al.

Image: Daniel S. Kohane, Harvard Medical School, Boston Children’s Hospital; Tianjiao Ji, National Center for Nanoscience and Technology; Xin Zhou, Fantastic Color Co., Ltd. Cover design: Allen Beattie.

Editorial

Increasingly translational delivery

The newest strategies for delivering therapeutics to specific cells and tissues are increasingly translationally promising.

Collection:

Delivery of drugs and biologics
Editorial 06 Oct 2021
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News & Views

Lipid nanoparticles for the inhalation of mRNA

Lipid nanoparticles can be optimized for the efficient delivery of mRNA via nebulization.

Rachel Yoon Kyung Chang
Hak-Kim Chan

Collection:

Delivery of drugs and biologics
News & Views 06 Oct 2021

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Reviews

The evolution of commercial drug delivery technologies

This Review Article discusses how delivery challenges associated with small molecules, nucleic acids, peptides, proteins and cells led to the development of commercial products and are now informing the delivery of live-cell therapeutics.

Ava M. Vargason
Aaron C. Anselmo
Samir Mitragotri

Collection:

Delivery of drugs and biologics
Review Article 01 Apr 2021

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Research

Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

Intravitreally injected exosomes derived from regulatory T cells and conjugated with an antibody for vascular endothelial growth factor via a cleavable linker markedly suppress ocular neovascularization in mice and non-human primates.

Ying Tian
Fan Zhang
Wei Wei

Collection:

Delivery of drugs and biologics
Article 26 Jul 2021
Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin

Orally delivered nanocarriers of insulin or rapamycin made from a polymeric bile acid exert metabolic and immunomodulatory functions, restore blood-glucose levels in mice and pigs with type 1 diabetes, and delay the onset of diabetes in mice.

Jung Seok Lee
Patrick Han
Tarek M. Fahmy

Collection:

Delivery of drugs and biologics
Article 06 Oct 2021
Transdermal microneedles for the programmable burst release of multiple vaccine payloads

Patches of transdermal core–shell microneedles, fabricated via additive manufacturing of polymer shells with varying degradability kinetics, enable the preprogrammed burst release of vaccine payloads over a period of a few days to more than a month.

Khanh T. M. Tran
Tyler D. Gavitt
Thanh D. Nguyen

Collection:

Delivery of drugs and biologics
Article 23 Nov 2020
Cryomicroneedles for transdermal cell delivery

Cryogenic microneedle patches can deliver mammalian cells before dissolving into the skin, as shown with the transdermal delivery of ovalbumin-pulsed dendritic cells in mice with subcutaneous tumours.

Hao Chang
Sharon W. T. Chew
Chenjie Xu

Collection:

Delivery of drugs and biologics
Article 03 May 2021
Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity

Conjugates of small-molecule anticancer drugs with a polyzwitterion that has negligible interaction with proteins and a weak interaction with phospholipids eradicate large tumours and patient-derived tumour xenografts in mice.

Siqin Chen
Yin Zhong
Youqing Shen

Collection:

Delivery of drugs and biologics
Article 15 Apr 2021
Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

A hydrogel implanted into the cavity of a resected tumour and releasing CAR-T cells and platelets conjugated with a checkpoint inhibitor inhibits local tumour recurrence and the growth of distant tumours in mice.

Quanyin Hu
Hongjun Li
Zhen Gu

Collections:

Implanted biomaterials

Delivery of drugs and biologics
Article 26 Apr 2021
Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Nanoparticles releasing an oxaliplatin prodrug and a cationic DNA intercalator within temozolomide-resistant gliomas in mice after convection-enhanced delivery inhibit the growth of the tumours without causing any detectable toxicity.

Yongheng Wang
Yuhang Jiang
W. Mark Saltzman

Collection:

Delivery of drugs and biologics
Article 27 May 2021
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Lipid nanoparticles can be optimized for the efficient delivery of therapeutic mRNAs to the lung via nebulization, as shown for the delivery of a therapeutic antibody in mice challenged with a lethal dose of the H1N1 influenza A virus.

Melissa P. Lokugamage
Daryll Vanover
James E. Dahlman

Collections:

SCGE

Delivery of drugs and biologics
Article 06 Oct 2021
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

An intra-articularly injected depot of nanoparticles targeting collagen and delivering small interfering RNA for matrix metalloproteinase 13 protects cartilage integrity and joint structure in mice with post-traumatic osteoarthritis.

Sean K. Bedingfield
Juan M. Colazo
Craig L. Duvall

Collection:

Delivery of drugs and biologics
Article 19 Aug 2021
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

The loading of two different protein therapeutics onto extracellular vesicles can be optimized by genetically engineering the parent cells, as shown for extracellular vesicles displaying decoy receptors for two pro-inflammatory cytokines.

Dhanu Gupta
Oscar P. B. Wiklander
Samir El-Andaloussi

Collections:

Extracellular vesicles

Delivery of drugs and biologics
Article 06 Oct 2021
Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel

A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.

Tianjiao Ji
Yang Li
Daniel S. Kohane

Collection:

Delivery of drugs and biologics
Article 13 Sept 2021

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Volume 5 Issue 9, September 2021

Prolonged local anaesthesia via nanofibres mimicking interactions on a sodium channel

Editorial

Increasingly translational delivery

News & Views

Lipid nanoparticles for the inhalation of mRNA

Reviews

The evolution of commercial drug delivery technologies

Research

Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells

Metabolic and immunomodulatory control of type 1 diabetes via orally delivered bile-acid-polymer nanocarriers of insulin or rapamycin

Transdermal microneedles for the programmable burst release of multiple vaccine payloads

Cryomicroneedles for transdermal cell delivery

Enhanced tumour penetration and prolonged circulation in blood of polyzwitterion–drug conjugates with cell-membrane affinity

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance

Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs

Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage

Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

Delivery of local anaesthetics by a self-assembled supramolecular system mimicking their interactions with a sodium channel

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