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The sustained expression of RNA-targeting Cas9 delivered intramuscularly or systemically by adeno-associated viral vectors eliminates pathogenic foci of expanded-repeat transcripts and reverses muscle-disease phenotypes in mouse models of myotonic dystrophy type 1.
Subretinal delivery of lentiviruses bearing Cas9 mRNA and a guide RNA targeting the Vegfa gene reduces the development of choroidal neovascularization in a mouse model of wet age-related macular degeneration.
By using CRISPR and transposon constructs, pigs have been genetically modified to inactivate endogenous retroviruses and to enhance the compatibility of their organs with the human immune and coagulation systems.
The DNA methylation of the promoter region of the oncogenic Yes-associated protein is reversibly regulated by the stiffness of the extracellular matrix.
The capacity of mesenchymal stromal cells to promote vascular regeneration in vivo can be enhanced by the combination of specific small-molecule inhibitors and the right waveform of mechanical stretch.
A minimally invasive microneedle patch detects specific protein biomarkers in dermal interstitial fluid at high sensitivity via a needle-integrated immunoassay coupled with an ultrabright fluorescent label.
Data from consumer smartwatches can improve the detection of COVID-19 when combined with symptom self-reporting, and can also detect the disease in pre-symptomatic individuals.
Systemically injected lipid–polymer nanoparticles delivering small interfering RNAs into bone-marrow endothelium modulate leukocyte trafficking from the bone marrow to the blood.
Systemic viral delivery of a gene encoding for a light-sensitive red-shifted ion channel enables non-invasive neuronal stimulation deep in the brain of rodents.
Wearable piezoelectric thin films integrated with multiphysics modelling and three-dimensional digital image correlation can decode facial expressions in real time.
Narrow-bandwidth signals and relaxed neural-recording parameters can substantially reduce the power requirements of brain–machine interfaces without degrading their performance.
Microwell arrays enable the culture of thousands of organoids with increased homogeneity, and facilitate high-content image-based analyses and high-throughput drug screens.
The oral delivery of a microencapsulated bacterial cocktail into animal models of kidney disease promotes the degradation of nitrogenous waste in the gut, thereby supporting renal function.
Positron emission tomography enables the tracking, in a mouse, of an intravenously injected cell radiolabelled with mesoporous silica nanoparticles containing 68Ga.
