Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Off-target genome editing in the liver can be reduced by using lipid nanoparticles to deliver oligonucleotides that disrupt the secondary structure of single-guide RNAs as well as short interfering RNAs targeting Cas9 mRNA.
An electromechanical chip consisting of self-assembled DNA-based cantilevers immobilized on a liquid-gated graphene field-effect transistor can be configured to rapidly detect ultra-low concentrations of biomolecules, including viral nucleic acids, in biological fluids.
Coating mesenchymal stromal cells with a soft gel incorporating specific chemomechanical cues that enhance the production of collagenases enhances the ability of the cells to inhibit aberrant tissue remodelling in mice with fibrotic lungs.
Flagellated bacteria coated with antigen-adsorbing nanoparticles and injected into irradiated tumours elicit systemic antitumour immune responses by transporting tumour antigens towards the tumour periphery, where they are taken up by functional antigen-presenting cells.
