Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Brush-like biopolymers mimicking the lubrication properties of natural cartilage-binding complexes in articular joints enhance cartilage regeneration in a rat model of early osteoarthritis.
Injectable and electrically conductive scaffolds displaying shape-memory behaviour and a hierarchical porous structure enhance the functional repair of infarcted heart muscle in rats and minipigs.
Orthogonally conjugating the cytokine interleukin-2 to poly(ethylene glycol) moieties at defined protein sites improves its pharmacokinetics and half-life as well as its therapeutic performance in mouse models of autoimmune diseases.
A self-assembling supramolecular delivery system for site-1 sodium channel blockers designed to mimic specific interactions on voltage-gated sodium channels led to prolonged nerve blockade and to reduced systemic toxicity in rats.
In mouse models of hereditary tyrosinaemia and of Leber congenital amaurosis, prime editing can precisely correct the disease-causing mutations, ameliorating the disease phenotypes.
Mouse fibroblasts can be simultaneously directly reprogrammed into cardiomyocytes, endothelial cells and smooth muscle cells to form cardiac tissue structures that improve cardiac function on implantation into infarcted mouse hearts.
An intra-articularly injected depot of nanoparticles targeting collagen and delivering small interfering RNA for matrix metalloproteinase 13 protects cartilage integrity and joint structure in mice with post-traumatic osteoarthritis.
A soft and lightweight neuroprosthetic hand that offers simultaneous myoelectric control and tactile feedback outperformed a conventional rigid neuroprosthetic hand in speed and dexterity.
The activity of engineered T cells within tumours can be controlled via the heat generated by pulses of focused ultrasound by modifying the cells to express a chimeric antigen receptor under the control of a promoter for the heat-shock protein.
Spatial control of the production of immunomodulatory biologics by CAR T cells engineered with synthetic gene switches that respond to mild elevations in temperature enhances the cells’ antitumour activity.
A microphysiological model of ischaemic stroke consisting of a functional neurovascular unit on a microfluidic chip allows for the systematic characterization of the neurorestorative outcomes of candidate stem cell therapies.
Glutathione-capped copper–indium–selenium nanotubes that display phosphorescence in acidic environments facilitate enhanced tumour-specific imaging in the second near-infrared spectral window.
Protection of the endothelial glycocalyx in vascular allografts via the enzymatic ligation of immunosuppressive glycopolymers prevents allograft rejection after transplantation in the absence of systemic immunosuppression.
A protocol for the selective differentiation of human pluripotent stem cells into expandable PRRX1+ limb-bud-like mesenchymal cells allows for the prospective assessment of the cells’ chondrogenic potential and the formation of hyaline cartilaginous-like particles.
An adhesive paste designed to mimic some properties of barnacle glue haemostatically seals tissues robustly in less than 15 s, independently of the rate of blood coagulation.
Human natural killer cells with potent anticancer activity can be directly reprogrammed from somatic cells using pluripotency transcription factors and an optimized reprogramming medium.
Cellular signalling networks in the microenvironment of implanted biomaterial scaffolds can be computationally reconstructed from single-cell RNA-sequencing data of cells collected from the implantation site.
Aminoacyl-tRNA-synthase–tRNA pairs specific for the desired unnatural amino acids can read through a nonsense mutation in the dystrophin gene, and partially restore muscle function in mice.
Brain-wide Cas9-mediated cleavage of a disease-causing gene after a single intravenous or intrahippocampal injection alleviates amyloid-beta-associated pathologies in mouse models of familial Alzheimer’s disease.