Volume 21 Issue 10, October 2016

Embryonic cerebral cortex layering in WT and Dvl mutant mice. Representative images of coronal sections of WT (left) and Dvl1^−/−; Dvl3^+/− mutant (right) embryonic brains at E18.5 were immunostained anti-Ctip2 (Green) and anti-Cux1 (Red), as well as with DAPI (Blue). There is a specific reduction of the deep layer (Ctip2+) neurons at E18.5. This reduction is preceded by transient brain overgrowth at E14.5 associated with increased neural progenitor proliferation and premature differentiation. For more info on this topic, please refer to the article by Belinson et al on pages 1417–1433.