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Chronic lymphocytic leukemia: recent advances in biology and therapy
In this special supplement to Leukemiawe present several recently published reports which highlight where chronic lymphocytic leukemia research is headed.
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Therapy advances in chronic myelogenous leukemia (CML)
The articles in this Focus collection highlight new developments in our understanding and management of persons with CML.
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Clonal Evolution
The clonal evolution spotlight series will provide comprehensive reviews on the evolutionary aspects of common hematopoietic malignancies. The reviews will cover key topics including biological principles guiding the evolutionary process, methodological considerations, and importantly, a perspective on applying this knowledge to improve patient care.
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Epigenetics in Hematologic Malignancies
“Epigenetics” refers to changes in the gene expression occurring without alterations in DNA sequence. Accumulating evidence indicates that epigenetic abnormalities may underlie the pathogenesis of many types of leukemia. Accordingly targeting these abnormalities is a very plausible approach to leukemia therapy. These possibilities have prompted Leukemia to publish an “Epigenetics in Hematologic Malignancies” focus collection. The papers in the collection range from the more “basic” to the more “clinical”.
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miRNA and Hematopoiesis
In this focus collection we will provide comprehensive reviews by experts in the field that cover a range of topics including the biological and clinical value of miRNAs in leukemia, normal hematopoiesis and the immune system, the tight epigenetic control of the miRNA machinery, a critical evaluation of methods for target gene prediction and functional studies and the clinical interference with miRNA function as new treatment options in leukemia.
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Follicular helper T cells
Follicular helper T cells (TFH) are able to closely interact with B cells to promote the formation of germinal centers (GCs). The stable cognate interaction between TFH and B cells in the GC is mutually beneficial to both cells for their development and function. Specifically, help B cells produce long-lived memory B cells and high-affinity antibodies and, in reciprocation, TFH cells are helped by B cells for further differentiation through cell cognation. This results in effective antibody responses to provide protection against pathogenic microbes. This focus presents links to related articles from across Springer Nature to provide more background information about these cells.
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Cancer Immunology
The January 2012 special issue presents two important strategies for generating potent and lasting anti-tumor immunity. The first strategy is to subvert immune suppressive networks in the tumor microenvironment. The second strategy is to optimize conventional and anti-biological modalities to directly target tumor and adjacent tumor tissue, and mobilize and expand anti-tumor immunity in the tumor microenvironment which results in tumor eradication. Further background information on this important topic is available through the accompanying web focus which links to related articles from across Springer Nature.
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Signaling pathways regulating HSC
This focus is dedicated to Prof. Ernest McCulloch who opened the way to modern stem cell studies and remains a vivid figure for all those working in the field today.
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Cutting edge issues in immunology and autoimmunity
In recent decades enormous effort has been made to elucidate the pathogenesis of autoimmune and autoinflammatory diseases. Autoimmunity is a multifactorial process in which genetic, immunological, environmental and hormonal factors act in concert, representing what was termed some years ago the “mosaic of autoimmunity”. The May 2011 Special Issue on Cutting Edge Issues in Immunology and Autoimmunity summarizes our current understanding of this complex mosaic. The accompanying selection of recent articles from across the Springer Nature provide further insight into this topic.
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Perspective on Stem Cell Homing and Mobilization
This collection of review articles covers recent advances in the understanding of the mechanisms which govern stem cell retention in the bone marrow and their mobilization into peripheral blood. An invaluable resource for practicing clinicians, laboratory scientists, and other hematologists. This Focus is dedicated to Prof. Ernest McCulloch who opened the way to modern stem cell studies and remains a vivid figure for all those working in the field today.
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Chronic Myeloid Leukemia
With this focus we seek to summarize recent advances in knowledge related to the pathogenesis of CML and indicate where these may have important therapeutic implications.