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Brønsted basicity can be greatly enhanced by the mechanical entanglement of two or more interlocked molecular subunits within catenanes and rotaxanes. Here, the authors discuss the development of such mechanically interlocked superbases, and outline challenges and opportunities for future directions of research.
Combinatorial biosynthesis of natural products is a method to synthesize structurally diverse molecules with defined modifications. Here, the authors review the various approaches used for combinatorial biosynthesis of fungal natural products by engineering biosynthetic enzymes and pathways to generate novel molecules.
Dynamic microscale droplets produced by liquid–liquid phase separation (LLPS) have emerged as appealing biomaterials, but their instability hinders their assembly into high-order structures with collective behaviors. Here, the authors review current strategies for stabilizing droplets, as well as recent developments in the applications of such LLPS droplets, and provide insights into how stabilized droplets can self-assemble into higher-order structures that display coordinated functions.
Liquid crystal elastomers are shape-morphing materials that demonstrate reversible actuation when exposed to external stimuli, and their actuation depends heavily on the liquid crystal alignment programmed into these materials, using various shape-programming processes. Here, the author reviews current shape-programming methods in relation to the challenges of employing liquid crystal elastomers as soft, shape-memory components in devices in the future.
The signal transducing interface between biosamples and detection devices plays a key role in translating electrochemical reactions into output signals and often governs detection limits and biocompatibility of the sensor. Here, the author reviews syntheses and properties of electrochemical interfaces of field-effect transistor-based biosensors.
Molecular fragmentation plays a pivotal role in medicinal chemistry and drug discovery. Here the authors summarize the methodologies for molecular fragmentation and their application in the AI-based fragment-based drug discovery.
