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Human bronchial epithelial cell-derived EVs exhibit immunomodulatory properties through miRNAs & ANXA1, which can suppress NF-κB signaling. The study holds promise as a novel approach for mitigating lung injury and inflammation in acute lung injury.
Golgin45, a Golgi structural protein, is heavily SUMOylated and heat shock stress increases Golgin45 SUMOylation modified by SUMO3 and promotes its inclusion into PML-NBs to transcriptionally regulate lipid metabolism genes.
Efficient phage synthesis yields O157 antigen-specific phages with the detection tag at optimal sites, enabling specific detection of diverse E. coli O157 clinical isolates and suggesting broad applications in bacterial detection and phage therapy.
A survey of known human DNA editing sites with an RNA editing site prediction algorithm suggests APOBEC-mediated RNA editing may produce some of the same protein variants, with the possibility of affecting multiple areas of health.
High levels of placental growth factor can result in a stiffer microenvironment milieu impeding trophoblast invasion of endometrial cells prior to pregnancy, providing insight into the pathogenesis of pre-eclampsia.
Personalized brain activity models in Alzheimer’s disease detect synergistic amyloid-β and tau impacts on neuronal excitability values, which significantly predict brain atrophy, p-tau217 plasma concentrations, and cognitive deterioration.
The authors present DMD-edited microminipigs showing severe Duchenne muscular dystrophy symptoms; their human-like physiology and small size make them ideal for developing new treatments.
A longitudinal study of the circulatory cellular immunity of individuals co-infected with recurrent visceral leishmaniasis and HIV suggests that T cell unresponsiveness underlies visceral leishmaniasis chronicity.
An fMRI study suggests that adaptation to sensorimotor delays when touching one hand with the other dynamically alters the activity in somatosensory and cerebellar regions.
The adaptor protein Disabled 2 (Dab2) regulates the activation and self-renewal of hair follicle stem cells via canonical Wnt pathway. Importantly, Dab2 is also involved in the ageing process.
The epigenetic regulator, N(alpha)-acetyltransferase 40 (NAA40), induced by ecdysone, acetylates histone H4 and modulates ecdysone action in the regulation of insect metamorphosis.
This study shows that severity of disease in COVID-19 patients is characterized by the preferential loss of TCF1+ progenitor T-cells needed to self-renew and replenish the immune system.
The fastest growing bacterium known is Vibrio natriegens. We have fused the two chromosomes of V. natriegens to create a single chromosome strain. Our results show that the bipartite genome is not a prerequisite for its rapid growth
Brain shape and function are intricately related, and the morphological pattern of the right IntraParietal Sulcus appears significantly related to human memory and language performance.
“A transcriptome study of chicken primary myoblast proliferation and differentiation shows that the lncMDP1/miRNA-301a-5p/CHAC1 axis plays an important role in skeletal muscle development.“
An fMRI study on a navigation task in multidimensional abstract spaces showed that the human hippocampus, entorhinal cortex, and orbitofrontal cortex collaborate in learning abstract space structures.
Introducing GenomeNet-Architect, a neural architecture design framework that automatically optimises the overall layout of the architecture, the hyperparameters, and the training procedure of deep learning models for genome sequence data.
Proteomic study of mild hypothermia in skeletal muscle myoblasts from mice shows that hypothermia enhances mitochondrial metabolism and differentiation via the cold shock protein RBM3 and its overexpression even at room temperature can recapitulate these effects.
A study about the development of a quantitative agent-based model of yeast colony growth reproducing colony size measurements at various environmental conditions, like altered humidity, nutrient gradients, or varied initial colony inoculation.
Neoantigens derived from somatic mutations in KRAS represent promising targets for cancer immunotherapy. Through structure-based design, the authors identify the KRAS-G12V specific affinity-enhanced TCR, offering great promise for advancing cancer immunotherapy.