Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
The SPP1 tail completion protein, representative of a widespread family of essential phage proteins, is shown to play a role in capsid-tail attachment and to be essential for routing of phage DNA from the viral particle to the bacterial cytoplasm.
Bat MHC-I’s AA insertions boost thermal stability and peptide diversity, potentially adapting to flight-induced high temperatures and improving antiviral defenses, suggesting an evolutionary strategy to body temperature changes.
Ehle et al. show that downregulation of the liver-identity factor HNF4A facilitates inflammation-associated acute phase gene expression at the expense of homeostatic hepatic functions, to promote the acute phase response.
A biochemical study discovers that the target site preferences of the DNA methyltransferase DNMT3C differ from its relatives DNMT3A and DNMT3B and they specifically match the biological repeat elements methylated by DNMT3C.
DNA methyltransferase inhibitors potentiate anti-tumor immunity by inducing tumor immunogenicity and improving antigen processing through the STING-dependent type I interferon response.
An in vitro study on fibroblasts from clinically affected or unaffected skin of patients with Pseudoxanthoma elasticum indicates that local microenvironment guides the level of matrix remodeling and the extent of elastic fiber calcification.
A study suggests that rifleman – one of the two extant species of New Zealand wrens, the most basal Passeriformes in birds – has predispositions for vocal production learning, including group vocal signatures, vocal convergence, and phenotypic variance call ratios similar to vocal learners.
Prodromal gut inflammation exacerbates Parkinson’s disease endophenotypes in mouse carriers of human LRRK2 G2019S in a sex-dependent manner, showing increased α-synuclein positive macrophages in the colon and brain microglia.
This study on how Staphylococcus aureus manipulates host-derived fatty acids reveals that a bacteriallipase (Lip2) converts toxic fatty acids and cholesterol into innocuous cholesteryl esters.
An in vitro and in vivo study using human melanoma cell lines suggests that perturbing lysosomal function stimulates lysosome biogenesis and decreases invasiveness potential.
A computational study describing a parallel extension to software “STochastic Engine for Pathway Simulation" that simulates vesicles and their interactions with the cellular environment, including endocytosis, docking, fusion and active transport.
A study found that circFOXP1 was highly expressed in gastric cancer (GC) and demonstrated that ALKBH5-mediated m6A modification of circFOXP1 promoted GC progression by regulating SOX4 expression and sponging miR-338-3p.
A high-resolution structure provides a mechanistic explanation to the synthetic selectivity of quinolone synthase (AmQNS) and possible consequences of functionally relevant residue mutations.
Using multi-isotope analysis of tooth enamel of reindeer, equids and mammoth from the archaeological sites of Königsaue and Breitenbach, the authors identify shifts in ranging behaviour of these hominin prey species during the Last Glacial Period in Central Germany.
EP4 receptor enhances OSCC cell migration through increased Ca2+ signaling, linking to CALML6 and the CaMKK2 pathway. This process promotes mitochondrial function and metastasis, with CaMKK2 emerging as a potential target for OSCC treatment.
This study shows that the soil microbial community and herbivory both influence the assembly of the plant-associated microbial communities, but their effects are generated through different mechanisms.
An orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at the ERα binding site between the PROTAC and a linker metabolite.
An NMR study on the SIB1-WRKY33 interaction identifies the minimal sequence in SIB1 that is essential for complex formation and provides a structural model for understanding how SIB1 regulates the DNA binding activity of WRKY33.
Cryptophyte PSI-CAC structures revealed the differences in protein composition and CAC organization of PSI complex in exponential and stationary growth phases, which might be involved in the binding and energy transfer of lumenal phycobiliproteins.