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A large-scale analysis of genome-wide association studies links type 2 diabetes with gastrointestinal disorders, implicating causal associations, shared genes and biological pathways.
7-dimensional niche space of 191 primate species shows niche diversity is partitioned unequally. Interspecific competition is lowest in great apes and highest in callitrichids.
Using in vivo two-photon microscopy, the structural dynamics of synapses in the prefrontal cortex of an autism model marmoset were studied. In the marmoset, clustered dendritic spine generation was heightened, which was attenuated by oxytocin.
A study on mice without fast-isoform Myosin Binding Protein C (MyBP-C) suggests that this isoform is a critical determinant of contraction performance via control of sarcomeric motor proteins.
A genome-wide association study in a cohort of 63,992 Danish blood donors identified an association between complete freedom from headache and a locus in the ADARB2 gene. The association was replicated in a cohort of 13,032 Danish blood donors.
The unique structural features of the NopD catalytic domain, an effector protease from symbiotic bacteria rhizobia, grant a surprising versatility to remove various regulatory tags (SUMO, ubiquitin, Nedd8) from host plant proteins.
Structural analysis using cryo-EM reveals that albicin, an inhibitor of the alternative pathway of complement from the saliva of a mosquito, binds the C3bBb complex through contacts with both chains of C3b as well as the protease factor B.
Nesfatin-1 and nesfatin-1-like peptide reduced lipid content in oleic acid-induced HepG2/C3A cells, an effect that was blocked by an AMPK inhibitor compound C. This highlights the therapeutic potential for nesfatin-1 and NLP in lipid disorders.
The Music frogs are revealed to possess adaptative flexibility under climate changes. Mud nests evolved as a key innovation during perennial high temperatures and precipitations but lost in certain descendants when the weather got dryer and colder.
Genome sequencing of the eastern quoll, an endangered marsupial, describes historical population declines and identifies the likely basis of its colour differences with the closely related Tasmanian devil.
A computational modeling study indicates that relative amount and timing of Ebola virus proteins VP40 and NP drive effective viral particle production.
Tardigrade secretory-abundant heat soluble (SAHS) proteins protect biological structures such as liposomes and microbial cells from dehydration-induced damages, potentially through undergoing structural transition upon desiccation.
Deletion of the ghrelin receptor (GHSR) gene protects against diet-induced obesity and decreases food intake during a high-fat diet in male but not female rats. Inverse agonism of brain GHSR attenuates ghrelin-induced food intake only in male mice.
A meta-analysis of original FSHD transcriptomic data confirms existing knowledge about DUX4 expression and mitochondrial deficits and reveals misregulation of the neuromuscular junction, nuclear envelope, and spliceosome.
The authors present SpatialPrompt, a tool that offers high accuracy and scalability for spot deconvolution and domain identification in spatial transcriptomics, showing superior performance on diverse spatial datasets.
A brain imaging study shows that humans with more complex cortical folds in a premotor brain region have a higher capacity to learn a challenging new motor skill during six weeks of practice.
Error-prone artificial DNA synthesis (epADS) is presented as an effective method for in vitro generation of genetic diversity for directed evolution of various types of genetic parts, synthetic gene circuits and even microbes.
Annotated structural atlas of cytokines and cytokine receptors featuring hotspots in a unified format, help to understand the mechanisms of cytokine-mediated signal transduction pathways and formulate therapeutic strategies.
The CYR1 mutation can enhance a strain’s thermotolerance and ability to produce high yields of recombinant protein by simultaneously strengthening stress resistance and the energy system through cAMP signalling cascades.