Metabolism in 3D

Beyond blueprints - p495

doi:10.1038/nchembio.997

Renewed interest in the biological significance and applied outcomes of metabolism is moving the field from static biochemical charts to multidimensional networks.

Full Text - Beyond blueprints | PDF (63 KB) - Beyond blueprints

Metabolism in 3D

Teaching the design principles of metabolism - pp497 - 501

Joshua D Rabinowitz & Livia Vastag

doi:10.1038/nchembio.969

Learning metabolism inevitably involves memorizing pathways. The teacher's challenge is to motivate memorization and to help students progress beyond it. To this end, students should be taught a few fundamental chemical reaction mechanisms and how these are repeatedly used to achieve pathway goals. Pathway knowledge should then be reinforced through quantitative problems that emphasize the relevance of metabolism to bioengineering and medicine.

Full Text - Teaching the design principles of metabolism | PDF (331 KB) - Teaching the design principles of metabolism

Metabolism in 3D

Rethinking glycolysis: on the biochemical logic of metabolic pathways - pp509 - 517

Arren Bar-Even, Avi Flamholz, Elad Noor & Ron Milo

doi:10.1038/nchembio.971

Abstract - Rethinking glycolysis: on the biochemical logic of metabolic pathways | Full Text - Rethinking glycolysis: on the biochemical logic of metabolic pathways | PDF (876 KB) - Rethinking glycolysis: on the biochemical logic of metabolic pathways

Metabolism in 3D

Engineering synthetic recursive pathways to generate non-natural small molecules - pp518 - 526

Elizabeth A Felnagle, Asha Chaubey, Elizabeth L Noey, Kendall N Houk & James C Liao

doi:10.1038/nchembio.959

Abstract - Engineering synthetic recursive pathways to generate non-natural small molecules | Full Text - Engineering synthetic recursive pathways to generate non-natural small molecules | PDF (1.23 MB) - Engineering synthetic recursive pathways to generate non-natural small molecules

Metabolism in 3D

Natural strategies for the spatial optimization of metabolism in synthetic biology - pp527 - 535

Christina M Agapakis, Patrick M Boyle & Pamela A Silver

doi:10.1038/nchembio.975

Abstract - Natural strategies for the spatial optimization of metabolism in synthetic biology | Full Text - Natural strategies for the spatial optimization of metabolism in synthetic biology | PDF (700 KB) - Natural strategies for the spatial optimization of metabolism in synthetic biology

Metabolism in 3D

Systems metabolic engineering of microorganisms for natural and nonnatural chemicals - pp536 - 546

Jeong Wook Lee, Dokyun Na, Jong Myoung Park, Joungmin Lee, Sol Choi & Sang Yup Lee

doi:10.1038/nchembio.970

Abstract - Systems metabolic engineering of microorganisms for natural and nonnatural chemicals | Full Text - Systems metabolic engineering of microorganisms for natural and nonnatural chemicals | PDF (1.1 MB) - Systems metabolic engineering of microorganisms for natural and nonnatural chemicals