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Cancer immunotherapy

  • In this Supplement

  • Cancer immunotherapy is a rapidly advancing field with relevance for an expanding list of tumour types. In this collection, Nature presents seven recent articles on cancer immunotherapy. Collectively, they investigate the efficacy and immunological effects of various checkpoint-blockade therapies in both clinical settings and pre-clinical models, explore strategies for the identification of immunogenic tumour antigens, and show that tailored neo-epitope-based vaccines can control tumour growth.

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    Cover Art: Allison Bruce

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  • Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer

    • Christina Twyman-Saint Victor
    • Andrew J. Rech
    • Amit Maity
    • Ramesh Rengan
    • Kristen E. Pauken
    • Erietta Stelekati
    • Joseph L. Benci
    • Bihui Xu
    • Hannah Dada
    • Pamela M. Odorizzi
    • Ramin S. Herati
    • Kathleen D. Mansfield
    • Dana Patsch
    • Ravi K. Amaravadi
    • Lynn M. Schuchter
    • Hemant Ishwaran
    • Rosemarie Mick
    • Daniel A. Pryma
    • Xiaowei Xu
    • Michael D. Feldman
    • Tara C. Gangadhar
    • Stephen M. Hahn
    • E. John Wherry
    • Robert H. Vonderheide
    • Andy J. Minn
    • Andy J. Minn

    Nature 520, 373-377 ()

  • Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

    • Roy S. Herbst
    • Jean-Charles Soria
    • Marcin Kowanetz
    • Gregg D. Fine
    • Omid Hamid
    • Michael S. Gordon
    • Jeffery A. Sosman
    • David F. McDermott
    • John D. Powderly
    • Scott N. Gettinger
    • Holbrook E. K. Kohrt
    • Leora Horn
    • Donald P. Lawrence
    • Sandra Rost
    • Maya Leabman
    • Yuanyuan Xiao
    • Ahmad Mokatrin
    • Hartmut Koeppen
    • Priti S. Hegde
    • Ira Mellman
    • Daniel S. Chen
    • F. Stephen Hodi
    • Roy S. Herbst

    Nature 515, 563-567 ()

  • PD-1 blockade induces responses by inhibiting adaptive immune resistance

    • Paul C. Tumeh
    • Christina L. Harview
    • Jennifer H. Yearley
    • I. Peter Shintaku
    • Emma J. M. Taylor
    • Lidia Robert
    • Bartosz Chmielowski
    • Marko Spasic
    • Gina Henry
    • Voicu Ciobanu
    • Alisha N. West
    • Manuel Carmona
    • Christine Kivork
    • Elizabeth Seja
    • Grace Cherry
    • Antonio J. Gutierrez
    • Tristan R. Grogan
    • Christine Mateus
    • Gorana Tomasic
    • John A. Glaspy
    • Ryan O. Emerson
    • Harlan Robins
    • Robert H. Pierce
    • David A. Elashoff
    • Caroline Robert
    • Antoni Ribas
    • Paul C. Tumeh
    • Antoni Ribas

    Nature 515, 568-571 ()

  • Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

    • Matthew M. Gubin
    • Xiuli Zhang
    • Heiko Schuster
    • Etienne Caron
    • Jeffrey P. Ward
    • Takuro Noguchi
    • Yulia Ivanova
    • Jasreet Hundal
    • Cora D. Arthur
    • Willem-Jan Krebber
    • Gwenn E. Mulder
    • Mireille Toebes
    • Matthew D. Vesely
    • Samuel S. K. Lam
    • Alan J. Korman
    • James P. Allison
    • Gordon J. Freeman
    • Arlene H. Sharpe
    • Erika L. Pearce
    • Ton N. Schumacher
    • Ruedi Aebersold
    • Hans-Georg Rammensee
    • Cornelis J. M. Melief
    • Elaine R. Mardis
    • William E. Gillanders
    • Maxim N. Artyomov
    • Robert D. Schreiber
    • Robert D. Schreiber

    Nature 515, 577-581 ()

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