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Frontiers in biology

Vol. 493 No. 7432 pp317-363

In this Supplement
- Editorial
- Articles
Reviews in this Insight, which highlights important advances in biology, include self-organization of tissues, Fanconi anaemia and its links to genomic stability, the possibility of slowing ageing with drugs that target mTOR, metabolism of inflammation and how this is limited by AMPK activation, and the role of neuron signalling in autism.

Credit: Nik Spencer

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Cytosystems dynamics in self-organization of tissue architecture
- Yoshiki Sasai
Nature 493, 318-326 (17 January 2013)
Activity-dependent neuronal signalling and autism spectrum disorder
- Daniel H. Ebert
- Michael E. Greenberg
Nature 493, 327-337 (17 January 2013)
mTOR is a key modulator of ageing and age-related disease
- Simon C. Johnson
- Peter S. Rabinovitch
- Matt Kaeberlein
Nature 493, 338-345 (17 January 2013)
Metabolism of inflammation limited by AMPK and pseudo-starvation
- Luke A. J. O'Neill
- D. Grahame Hardie
Nature 493, 346-355 (17 January 2013)
Fanconi anaemia and the repair of Watson and Crick DNA crosslinks
- Molly C. Kottemann
- Agata Smogorzewska
Nature 493, 356-363 (17 January 2013)