[Special Feature] 4D Nucleome: Dynamic Three-dimensional Genome Organization Over Time

The chromatin architecture of mammalian genomes exhibits a complex, multilayered three-dimensional structure. The spatial folding of chromosomes and their organization in the nucleus have profound effects on gene expression and cellular function, and changes in nuclear organization affect both normal development and various diseases. Investigating the three-dimensional organization of DNA within the nucleus, along with its temporal dynamics, constitutes a primary focus of research in the 4D Nucleome Project. This special issue provides comprehensive reviews of technological advances to investigate the 3D organization of the DNA in the nucleus and the functional implication of 4D Nucleome in physiology and human disease.