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Graft-Versus-Host Disease

Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation

Bone Marrow Transplantation volume 36, pages 151–156 (2005)Cite this article

Summary:

CD31 gene polymorphisms are implicated in the pathogenesis of graft-versus-host disease (GvHD) following haematopoietic stem cell transplantation (HST). We investigated the influence of CD31 genotype on the incidence of GvHD following HST from an human leukocyte antigen (HLA)-identical sibling donor. Donor and recipient CD31 codons 125, 563 and 670 DNA polymorphisms were determined in 85 cases of HLA identical sibling HST from two transplant centres. A correlation between CD31 genotype and acute GvHD was considered significant if observed in patients from both transplant centres independently. A strong correlation was identified between donor CD31 codon 125 genotype and the incidence of acute GvHD. Acute GvHD grades II–IV occurred in 27 of 46 (59%) recipients with a CD31 codon 125 leucine / valine heterozygous donor compared to nine of 39 (23%) recipients with a CD31 codon 125 homozygous donor (P=0.0019, relative-risk 2.45, 95% confidence interval 1.3–4.5). This correlation was significant in patients from both transplant centres (P=0.015 and P=0.019). We suggest that CD31 genotype may influence the function of donor-derived leukocytes and may be informative when there is a choice of comparable donors.

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Author notes

  1. P C Evans: PCE is a senior fellow of the National Kidney Research Foundation.

Authors and Affiliations

  1. Tissue Typing Laboratory, Addenbrooke's Cambridge University Teaching Hospital Trust, Cambridge, UK

    R S Goodman & C J Taylor

  2. Adult Leukaemia Unit, Christie Hospital, Manchester, UK

    J Ewing

  3. British Heart Foundation, Cardiovascular Medicine, Imperial College Hammersmith Campus, London, UK

    P C Evans

  4. Haematology Department Addenbrooke's Cambridge University Teaching Hospital Trust, Cambridge, UK

    J Craig & R E Marcus

  5. Transplantation Laboratory, Manchester Royal Infirmary, Manchester, UK

    K Poulton & P A Dyer

Authors
  1. R S Goodman
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  2. J Ewing
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  3. P C Evans
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  4. J Craig
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  5. K Poulton
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  6. P A Dyer
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  7. R E Marcus
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  8. C J Taylor
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Correspondence to R S Goodman.

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Goodman, R., Ewing, J., Evans, P. et al. Donor CD31 genotype and its association with acute graft-versus-host disease in HLA identical sibling stem cell transplantation. Bone Marrow Transplant 36, 151–156 (2005). https://doi.org/10.1038/sj.bmt.1705013

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