Summary
The relationships between risk of cervical dysplasia and dietary and serum carotenoids and vitamins were investigated in a case–control study. Cases were 156 women who attended Papanicolaou test screening in nine institutes affiliated with Japan Study Group of Human Papillomavirus (HPV) and Cervical Cancer and had cervical dysplasia newly histologically confirmed. Age-matched controls were selected from women with normal cervical cytology attending the same clinic. Blood sample and cervical exfoliated cells were obtained for measuring serum retinol, α-carotene, β-carotene, zeaxanthin/lutein, cryptoxanthin, lycopene and α-tocopherol and for HPV detection. Higher serum level of α-carotene was significantly associated with decreased risk of cervical dysplasia after controlling for HPV infection and smoking status (odds ratio (OR) = 0.16, 95% confidence interval (CI) 0.04–0.62 for the highest as compared with the lowest tertile). Decreased risk for the highest tertile of serum lycopene (OR = 0.28) was marginally significant. Decreased risks observed for the highest tertiles of β-carotene (OR = 0.65) and zeaxanthin/lutein (OR = 0.53), were not statistically significant.
Similar content being viewed by others
Article PDF
Change history
16 November 2011
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms, as noted at publication
References
Batieha, AW, Armenian, HK, Norkus, EP, Morris, JS, Spate, VE & Comstock, GW (1993). Serum micronutrients and the subsequent risk of cervical cancer in a population-based nested case–control study. Cancer Epidemiol Biomarkers Prev 2: 335–339.
Bernstein, A & Harris, B (1984). The relationship of dietary and serum vitamin A to the occurrence of cervical intraepithelial neoplasia in sexually active women. Am J Obstet Gynecol 148: 309–312.
Brock, KE, Mock, GBP, Maclennan, R, Truswell, AS & Brinton, LA (1988). Nutrients in diet and plasma and risk of in situ cervical cancer. J Natl Cancer Inst 80: 580–585.
Burton, GW & Ingold, KU (1984). β-carotene: an unusual type of lipid antioxidant. Science 224: 569–573.
Butterworth, CE, Hatch, KD, Macaluso, M, Cole, P, Sauberlich, HE, Soong, S, Borst, M & Baker, VV (1992). Folate deficiency and cervical dysplasia. J Am Med Assoc 267: 528–533.
Cuzick, J, De Stavola, BL, Russell, MJ & Thomas, BS (1990). Vitamin A, vitamin E and the risk of cervical intraepithelial neoplasia. Br J Cancer 62: 651–652.
De Vet, HCW, Knipschild, PG, Grol, MEC, Schouten, HJA & Sturmans, AF (1991). The role of beta-carotene and other dietary factors in the aetiology of cervical dysplasia: results of a case–control study. Int J Epidemiol 20: 603–610.
Harris, RWC, Forman, D, Doll, R, Vessey, MP & Wald, NJ (1986). Cancer of the cervix uteri and vitamin A. Br J Cancer 53: 653–659.
Herrero, R (1996). Epidemiology of cervical cancer. Monogr Natl Cancer Inst 21: 1–6.
Herrero, R, Potishman, N, Brinton, LA, Reeves, WC, Brenes, MM, Tenorio, F, De Brintton, RC & Gaitan, E (1991). A case–control study of nutrient status and invasive cervical cancer. Am J Epidemiol 134: 1335–1346.
Ito, Y, Ochiai, J, Sasaki, R, Suzuki, S, Kusuhara, Y, Morimitsu, Y, Otani, M & Aoki, K (1990). Serum concentrations of carotenoids, retinol, and α-tocopherol in healthy persons determined by high-performance liquid chromatograohy. Clin Chim Acta 194: 131–144.
Kwañniewska, A, Yukendorf, A & Semczuk, M (1996). Content of β-carotene in blood serum of human papillomavirus infected women with cervical dysplasia. Arch Immunol Ther Exp 44: 309–313.
La Vecchia, C, Decarli, A, Fasoli, M, Parazzini, F, Franceschi, S, Gentlie, A & Negri, E (1988). Dietary vitamin A and risk of intraepithelial and invasive cervical neoplasia. Gynecol Oncol 30: 187–195.
Marshall, JR, Graham, S, Byers, T, Swanson, M & Brasure, J (1983). Diet and smoking in the epidemiology of cancer of the cervix. J Natl Cancer Inst 70: 847–851.
Nells, HJCF & De Leenheer, AP (1983). Isocratic noaquenous reversed-phase liquid chromatography of carotenoids. Anal Chem 55: 270–275.
Palan, PR, Romney, SL, Nikham, M, Basu, J & Vermund, SH (1988). Decreased plasma beta-carotene levels in women with uterine cervical dysplasias and cancer. J Natl Cancer Inst 80: 454–455.
Palan, PR, Mikhail, MS, Basu, J & Romney, SL (1991). Plasma levels of antioxidant β-carotene and α-tocopherol in uterine cervix dysplasia and cancer. Nutr Cancer 15: 13–20.
Potischman, N & Brinton, LA (1996). Nutrition and cervical neoplasia. Cancer Causes Control 7: 113–126.
Potishman, N, Herrero, R, Brinton, LA, Reeves, WC, Staceicz-Spauntzakis, M, Jones, CJ, Brenes, MM, Tenorio, F, de Britton, RC & Gaitan, E (1991). A case–control study of nutrient status and invasive cervical cancer. II. Serological indicators. Am J Epidemiol 134: 1347–1355.
Romney, SL, Ho, GYF, Palan, PR, Basu, J, Kadish, AS, Klein, S, Mikhail, M, Hagan, RJ, Chang, CJ & Burk, RD (1997). Effects of β-carotene and other factors on outcome of cervical dysplasia and human papillomavirus infection. Gynecol Oncol 65: 483–492.
Schiffman, MH (1992). Validation of hybridization assays: correlation of filter in situ, dot blot and PCR with Southern blot. InThe Epidemiology of Human Papillomavirus and Cervical Cancer, Mujoz N, Bosch FX, Shah KV, Meheus A IARC Scientific Publication No. 119: Lyon 169–179.
Schneider, A & Shah, K (1989). The role of vitamins in the etiology of cervical neoplasia: an epidemiological review. Arch Gynecol Obstet 246: 1–13.
Shimizu, H, Nagata, C, Komatsu, S, Morita, N, Higashiiwai, H, Sugahara, N & Hisamichi, S (1996). Decreased serum retinol levels in women with cervical dysplasia. Br J Cancer 73: 1600–1604.
VanEenwyk, J, Davis, FG & Bowen, P (1991). Dietary and serum carotenoids and cervical intraepithelial neoplasia. Int J Cancer 48: 34–38.
Verreault, R, Chu, J, Mandelson, M & Shy, K (1989). A case–control study and invasive cervical cancer. Int J Cancer 43: 1050–1054.
Yoshikawa, H, Kawana, T, Kitagawa, K, Mizuno, M, Yoshikura, H & Iwamoto, A (1991). Detection and typing of multiple genital human papillomaviruses by DNA amplification with consensus primers. Jpn J Cancer Res 82: 524–531.
Yoshikawa, H, Nagata, C, Noda, K, Nozawa, S, Yajima, A, Sekiya, S, Sugimori, H, Hirai, Y, Kanazawa, K, Sugase, M, Shimizu, H & Kawana, T (1999). Human papillomavirus-independent risk factors for cervical intraepithelial neoplasia in Japan. Br J Cancer, (in press)
Ziegler, RG, Brinton, LA, Hamman, RF, Lehman, HF, Levine, RS, Mallin, LK, Norman, SA, Rosenthal, JF, Trumble, AC & Hoover, RN (1990). Diet and the risk of invasive cervical cancer among white women in the United States. Am J Epidemiol 132: 432–445.
Author information
Authors and Affiliations
Rights and permissions
From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
About this article
Cite this article
Nagata, C., Shimizu, H., Yoshikawa, H. et al. Serum carotenoids and vitamins and risk of cervical dysplasia from a case–control study in Japan. Br J Cancer 81, 1234–1237 (1999). https://doi.org/10.1038/sj.bjc.6690834
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.bjc.6690834
Keywords
This article is cited by
-
Association between serum carotenoids and bacterial vaginosis infection among American women
BMC Infectious Diseases (2024)
-
Association between carotenoids and outcome of cervical intraepithelial neoplasia: a prospective cohort study
International Journal of Clinical Oncology (2013)
-
Association between dietary calcium and vitamin D intake and cervical carcinogenesis among Japanese women
European Journal of Clinical Nutrition (2010)
-
The association between fruit and vegetable consumption and HPV viral load in high-risk HPV-positive women with cervical intraepithelial neoplasia
Cancer Causes & Control (2010)