Abstract
An experimental study was conducted to enhance regeneration in the spinal cord. Twenty Swiss albino rats were used, of which 8 were controls, and hemicordotomy was performed at mid-thoracic level. In 12 rats a segment of peripheral nerve (sciatic) autograft was taken, minced and implanted in the hemicordotomy site.
All the rats were sacrificed at 4–12 weeks. Fixation was carried out by intracardiac perfusion of fixative. Light microscopy was used to study the hemicordotomy site. Two observations were made; first, regeneration of the cord was greatly enhanced, and second, the spinal cord caudal to the hemicordotomy did not disintegrate in the grafted cords.
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Khalili, A., Hamash, M. Spinal cord regeneration: new experimental approach. Spinal Cord 26, 310–316 (1988). https://doi.org/10.1038/sc.1988.46
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DOI: https://doi.org/10.1038/sc.1988.46