Abstract
We describe the case of a paraplegic patient who suffered traumatic spinal cord injury at the level of the twelfth thoracic vertebra. Within a short period of time following the injury, urinary (neuropathic bladder) and gastrointestinal (atonic colon) sequelae arose. Treatment with Cisapride (R 51 619, Janssen Pharmaceutica) was undertaken in an attempt to increase colonic motility and to reduce urinary retention. These goals were reached rapidly with a dose of 10 mg q.i.d.; the effect has been maintained for at least 18 months since starting the therapy.
Similar content being viewed by others
Article PDF
References
Muller-Lissner SA and the Bavarian constipation study group 1987 Treatment of chronic constipation with cisapride and placebo. Gut 28(8): 1033–1038.
Reyntjens A, Verlinden M, Aerts T 1986 Development and clinical use of the new gastrointestinal prokinetic durg cisapride (R 51 619). Drug Development Research 8:251–265.
Schuurkes J A J, Van Nueten J M Van Daele PGH, Reyntjens A J, Janssen P A J 1985 Motor-stimulating properties of cisapride on isolated gastrointestinal preparations of the guinea pig. Journal of Pharmacology and Experimental Therapeutics 234:775–783.
Verlinden M, Schiettekatte L, Demyttenaere P, Vervaeke M, Goyvaerts H, Reyntjens A 1986 The effect of chronic administration of 5 and 10 mg of cisapride on moderate idiopathic constipation: a Belgian dose-response trial. Digestion 34:157.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Etienne, M., Verlinden, M. & Brassinne, A. Treatment with Cisapride of the gastrointestinal and urological sequelae of spinal cord transection: case report. Spinal Cord 26, 162–164 (1988). https://doi.org/10.1038/sc.1988.26
Issue Date:
DOI: https://doi.org/10.1038/sc.1988.26