Abstract
The sensitivity to penicillin of 255 Gram-negative urinary pathogens was determined to a maximum concentration of 200 units /ml. All strains of E. coli, nearly all strains of Providence and more than half the strains of Proteus mirabilis were inhibited by concentrations easily attainable in urine. All the other Gramnegative pathogens were resistant to 200 units ml.
Of the 30 strains of Providence twenty-three were of biotype 21 and seven of biotype 27, the in vitro sensitivity of the Providence strains against 12 antibiotics was determined. Nearly all strains were sensitive to pencillin and ampicillin, all strains were sensitive to trimethoprim and Kanamycin but only a few were sensitive to the other antibiotics.
Thirty-two paraplegic patients with Providence urinary infections were treated with Penicillin G 1,000,000 units 6-hourly for 6 to 10 days; Providence was eliminated in 30 patients, but there was a late recurrence in 5 patients.
It is concluded that penicillin is an effective antibiotic for the treatment of Providence urinary infection; it should also be considered for infections with E. coli and Proteus mirabilis which are resistant to other antibiotics.
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Abraham, E P, Chain, E, Fletcher, C M, Florey, H W, Gardner, A D, Heatley, N G & Jennings, M A (1941). Lancet, 2, 177.
Cook, G T (1946) Brit. med. J. 1, 955.
Exley, M (1946) J. Urol. 55, 435.
Ewing, W H, Tanner, K E & Dennard, D H (1954). J. infect. Dis. 94, 134.
Goodier, T E W & Parry, W R (1959). Lancet, 1, 356.
Gould, J C, Bowie, J H & Cameron, J D S (1952). Lancet, 1, 361.
Guttmann, L (1953) British History of the Second World War, Vol. Surgery, 474. London: H.M.S.O.
Holloway, W J & Scott, E G (1957). Antibiot. Med. 4, 104.
Hutchinson, R I & Randall, R J (1947). Lancet, 1, 22.
Middleton, J E (1958) J. clin. Path. 11, 270.
Milner, P R (1963) J. clin. Path. 16, 39.
Officer, R, Loewenthal, J & Perry, J W (1944). Med. J. Aust. 2, 473.
Peeney, A L P (1947) Proc. R. Soc. Med. 40, 433.
Shaw, C & Clark, P H (1955). J. gen. Microbial. 13, 155.
Yates Bell, J G (1947) Lancet, 2, 347.
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Read to Scientific Meeting of the International Medical Society of Paraplegia at Stoke Mandeville Hospital, 27 July 1963.
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Colley, E., Frankel, H. Penicillin G—treatment of urinary infection in paraplegia. Spinal Cord 2, 132–137 (1964). https://doi.org/10.1038/sc.1964.23
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DOI: https://doi.org/10.1038/sc.1964.23