Statins exert cardiovascular protective effects that are independent of cholesterol lowering. Using endothelial cells derived from induced pluripotent stem cells, Liu et al. show that statins can improve endothelial dysfunction by inhibiting endothelial–mesenchymal transition via epigenetic regulation of the GGTase–RhoA–YAP1–SOX9 signaling pathway.
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Acknowledgements
This work was supported by grants from the US National Heart, Lung, and Blood Institute (NHLBI; R01HL150877, R01HL156008) the National Research Foundation of Korea (NRF) funded by the Korean government (MSIT) (2020R1A2C3003784, 2020M3A9I4038454), and the Brain Korea 21 FOUR Project for Medical Science, Yonsei University College of Medicine.
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Y.Y. is a founder and equity holder in Karis Bio. The remaining authors declare no competing interests.
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Bae, S., Jung, C. & Yoon, Ys. Rescue of EndMT-associated endothelial dysfunction by modulating the YAP pathway. Nat Cardiovasc Res 2, 420–422 (2023). https://doi.org/10.1038/s44161-023-00268-0
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DOI: https://doi.org/10.1038/s44161-023-00268-0