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Apelin drives maintenance and expansion of the vascular niche in intestinal crypts

Nature Cardiovascular Research volume 1, pages 410–412 (2022)Cite this article

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Apelin is a multifunctional peptide that stimulates angiogenesis in a VEGF-A-dependent manner. A study now shows that apelin produced by intestinal endothelium drives VEGF-A-independent angiogenesis in intestinal crypts and is needed for the homeostasis of crypt-resident stem or progenitor cells.

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Fig. 1: The angiocrine apelin drives maintenance of the vascular niche and expansion in intestinal crypts.

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Acknowledgements

G.Y.K. acknowledges research support from the Korean Ministry of Science and ICT (IBS-R025-D1-2015).

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Authors and Affiliations

  1. Center for Vascular Research, Institute for Basic Science, Daejeon, South Korea

    Gou Young Koh

  2. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, South Korea

    Gou Young Koh

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  1. Gou Young Koh
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Correspondence to Gou Young Koh.

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Koh, G.Y. Apelin drives maintenance and expansion of the vascular niche in intestinal crypts. Nat Cardiovasc Res 1, 410–412 (2022). https://doi.org/10.1038/s44161-022-00071-3

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