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π–Twisted topologies

Paradromic molecules

Aromatic molecules with multiple one-half twists are synthesized using different precursors and synthetic routes. The pseudo-helicoidal structural chirality of these molecules and the loop of the twisted π-electronic structure fully overlap, thus giving rise to enhanced chiroptical responses.

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Fig. 1: Synthesis of triply twisted aromatic belts 1–3 that contain pentacyclic twisted units.

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Correspondence to Qian Miao or Juan Casado.

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Miao, Q., Casado, J. Paradromic molecules. Nat. Synth 2, 808–810 (2023). https://doi.org/10.1038/s44160-023-00320-8

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