Assembly and functionalization of biologically active steroids continue to pose a synthetic challenge. Now, mining and engineering of selective P450 C–H hydroxylases provide a biocatalytic C14–H hydroxylation, which can be integrated into chemoenzymatic syntheses of C14-functionalized steroids.
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Zhao, L., Bo, Z. & Yang, Y. Enzymes on steroids. Nat. Synth 2, 699–700 (2023). https://doi.org/10.1038/s44160-023-00287-6
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DOI: https://doi.org/10.1038/s44160-023-00287-6