Xu and colleagues used partial OSKM reprogramming in aged mice to drive cell-type proportions of the subventricular zone to more youthful levels, which equates to qualified rejuvenation of a neurogenic niche that is defined, in part, by restoration of neuroblast levels.
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Acknowledgements
N.C.A. is supported by a Postdoctoral Training Program for Research on Aging Grant T32 AG049672. Research in the laboratory of M.J.S. is supported by grants from the National Institutes of Health.
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Asmussen, N.C., Schafer, M.J. Partial reprogramming of the mammalian brain. Nat Aging 4, 440–442 (2024). https://doi.org/10.1038/s43587-024-00596-1
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DOI: https://doi.org/10.1038/s43587-024-00596-1