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Cardiac aging

SIRT2 counteracts primate cardiac aging

Nature Aging volume 3, pages 1178–1179 (2023)Cite this article

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Human aging is associated with increased rates of many cardiac diseases and tissue remodeling. However, disentangling the mechanisms that underlie normal heart aging from disease processes is challenging. A study now addresses this gap by investigating healthy primate cardiac aging and provides evidence that SIRT2 signaling may regulate cardioprotective effects.

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Fig. 1: Functional effect of SIRT2 changes across lifespan and across tissues.

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Authors and Affiliations

  1. Center for Precision Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Laura Cox & Michael Olivier

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  1. Laura Cox
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  2. Michael Olivier
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Correspondence to Laura Cox.

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The authors declare no competing interests.

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Cox, L., Olivier, M. SIRT2 counteracts primate cardiac aging. Nat Aging 3, 1178–1179 (2023). https://doi.org/10.1038/s43587-023-00496-w

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